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Diterpenoids from the roots of Croton oblongifolius |
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| Authors: | Youngsa-ad Witoon Ngamrojanavanich Nattaya Mahidol Chulabhorn Ruchirawat Somsak Prawat Hunsa Kittakoop Prasat |
| Affiliation: | Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand. |
| Abstract: | Two new clerodane diterpenes, methyl 15,16-epoxy-3,13(16),14- ENT-clerodatrien-18,19-olide-17-carboxylate ( 1) and dimethyl 15,16-epoxy-12-oxo-3,13(16),14- ENT-clerodatriene-17,18-dicarboxylate ( 2), together with seven known compounds ( 3 - 9), were isolated from the roots of Croton oblongifolius. The isolated compounds showed only mild cytotoxic activity against HuCCA-1, KB, HeLa, MDA-MB231, and T47D cell lines with IC (50) values ranging from 10 to 50 microg/mL. |
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