| 隐孢子虫动物模型的建立 |
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| 引用本文： | 郭步平,连德润. 隐孢子虫动物模型的建立[J]. 中国病原生物学杂志, 1997, 0(2) |
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| 作者姓名： | 郭步平 连德润 |
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| 作者单位： | 长治医学院寄生虫学教研室(郭步平)，中山医科大学寄生虫学研究所(连德润) |
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| 摘 要： | 本文通过饮水给予免疫抑制药和用人源隐孢子虫卵囊感染ＮＩＨ小鼠，建立了隐孢子虫感染小鼠模型。实验结果显示：免疫功能抑制组比正常组易感，两者感染度有显著性差异（Ｐ＜０．０５）。通过动物实验进一步证明免疫功能正常宿主感染隐孢子虫为自限性感染，免疫功能低下或缺陷者感染隐孢子虫可引起严重腹泻甚至死亡。
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| 关 键 词： | 微小隐孢子虫 动物模型 |
ANIMAL MODEL OF CRYPTOSPORIDIUM PARVUM |
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| Guo Bu-Ping ,Lian De-Run. ANIMAL MODEL OF CRYPTOSPORIDIUM PARVUM[J]. Journal of Pathogen Biology, 1997, 0(2) |
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| Authors: | Guo Bu-Ping Lian De-Run |
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| Affiliation: | Changzhi 046000 |
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| Abstract: | Mouse model for C. parvum was successfully established by Dexamethasone administered in drinking water and infection with oocysts of C. Parvum from a patient. The results showed that immunosuppressive mice were more easily infected than the immunocompetent one. The infectiosity of the former was much higher than that of the later(P<0.05). These data further confirmed that infection of C. parvum is self limiting in the immunocompetent host, and can cause life threatening diarrhea in immunodepressive or immunodeficient patients. |
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| Keywords: | Cryptosporidium parvun animal model |
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