| CTS-EDTA的合成与鉴定及其体外螯合Sr2+的研究 |
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| 引用本文： | 张刘珍,许玉杰,王畅,翁婉雯,丁文秀,杨占山. CTS-EDTA的合成与鉴定及其体外螯合Sr2+的研究[J]. 中国辐射卫生, 2009, 18(1) |
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| 作者姓名： | 张刘珍 许玉杰 王畅 翁婉雯 丁文秀 杨占山 |
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| 作者单位： | 苏州大学医学部放射医学与公共卫生学院,江苏,苏州,215123 |
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| 基金项目： | 国防科研基础研究项目(A3820060138) |
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| 摘 要： | 目的合成CTS-EDTA,并比较CTS与CTS-EDTA螯合Sr2+的能力。方法通过N-酰化反应合成CTS-EDTA,通过原子吸收光谱法比较CTS与CTS-EDTA螯合Sr2+的能力。结果红外图谱与核磁氢谱均证实成功合成了CTS-EDTA,体外实验表明CTS-EDTA螯合Sr2+的效率在10min后可达到80%以上,而CTS与Control(空白对照)无明显差异。结论N-酰化反应能合成CTS-EDTA,且CTS-EDTA螯合Sr2+的能力明显优于CTS。
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| 关 键 词： | 壳聚糖（CTS） 乙二胺四乙酸（EDTA） 红外光谱 核磁共振 火焰原子吸收光谱法 Sr~（2+） |
The Preparation and Characterization of CTS-EDTA and the Study of its Chelating Sr2+ in Vitro |
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| ZHANG Liu-zhen,XU Yu-jie,WANG Chang,et al.. The Preparation and Characterization of CTS-EDTA and the Study of its Chelating Sr2+ in Vitro[J]. Chinese Journal of Radiological Health, 2009, 18(1) |
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| Authors: | ZHANG Liu-zhen XU Yu-jie WANG Chang et al. |
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| Affiliation: | ZHANG Liu-zhen,XU Yu-jie,WANG Chang,et al.School of Radiation Medicine , Public Health,Medical College of Soochow University,Suzhou 215123 China |
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| Abstract: | Objective To obtain chitosan(CTS)-ehylene diamine tetraacetic acid(EDTA) compound(CTS-EDTA compound),and compare the chelating ability to Sr2+ of CTS and CTS-EDTA.Methods To synthesize CTS-EDTA compound by N-acylation reaction,and use atomic absorption spectrometry to measure the Sr2+ concentration changes in the SrCl2 solution with CTS and CTS-EDTA respectively.Results FTIR and 1H-NMR spectrum showed that CTS-EDTA compound was made successfully,and CTS-EDTA's chelating efficiency to Sr2+ was over 80% in 10... |
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| Keywords: | Sr2+ |
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