以骨质破坏为主的儿童恶性淋巴瘤临床及影像学特点

为初步探讨表现为骨质破坏的儿童恶性淋巴瘤临床及影像学特点、方案选择、疗效和预后，对6例表现为骨质破坏的儿童恶性淋巴瘤进行影像学检查、免疫组化检查、病理分型及选择方案化疗和放疗并长期随访。结果显示6例患儿CT和MRI检查均有不同骨质破坏，免疫分型为B型；采用MCP方案化疗后1例死亡，5例长期无病生存。提示表现为骨质破坏的恶性淋巴瘤临床少见报道，应通过影像学和病理检查及早确诊，可采用常规化疗方案结合放疗治疗，预后与临床分期相关。

Clinical and imaging features of childhood malignant lymphoma with destruction of bone

To explore the clinical and imaging features, treatment scheme and prognosis of childhood malignant lym-phoma with destruction of bone, the treatment and follow-up were undertaken in 6 cases who were diagnosed as malignant lymphoma with destruction of bone by imaging examination, immunohistochemical analysis and pathologic studies, respectively. The results showed that different destruction of bone was confirmed on both of CT and MRI.and B type in immunology was classified in these patients. All patients were in constant complete remission (CCR) after the treatment of the MCP scheme except one girl died. It is concluded that the imaging examination will be necessary for the early diagnosis of malignant lymphoma with destruction of bone although it is not common clinically. MCP scheme is valuable for the treatment of the disease, and the prognosis will be correlated to clinical stages.