Influence of ketanserin (serotonin antagonist) on bladder and urethral function |
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Authors: | K.P.J. Delaere M.D. F.M.J. Debruyne M.D. L.H.D.J. Booij M.D. |
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Affiliation: | 1. Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA;2. Department of Earth and Environment, Boston University, Boston, MA 02215, USA |
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Abstract: | As it is known that serotonin or 5-hydroxytryptamine can enhance bladder activity, we studied urodynamically the effect of ketanserin, a serotonin antagonist, in 17 patients, in the hope that this drug might be useful in treating unstable bladders. However, a relaxant effect on bladder contractility could not be demonstrated. On the contrary, a significant decrease of the urethral pressure was observed, suggesting that ketanserin might still have a possible role in promotion of bladder emptying. The relaxant effect on the urethra suggests some alpha-sympathicolytic activity of ketanserin. |
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