女性更年期高血压患者神经内分泌因素与动态血压的关系

目的探讨神经内分泌因素与女性更年期高血压患者24h血压节律的关系。方法采用放射免疫分析法检测78例女性更年期高血压患者血浆神经肽Y(NPY)、神经降压素(NT),应用统计学方法对检测结果进行分析,观察其与24h血压节律正常组(杓型组)及异常组(非杓型组)的关系。结果 78例高血压患者血浆NPY水平与24h平均收缩压、平均舒张压、平均动脉压均呈正相关;血浆NT水平与24h平均舒张压、平均动脉压呈负相关。结论女性更年期高血压患者血浆NPY、NT水平昼夜变化不同,二者含量的改变与血压波动相关。NPY、NT可能参与了高血压的发病过程,并促进其发生、发展。血浆NPY和NT水平在一定程度上可作为评估女性更年期高血压患者血压变化特点的指标之一。

Investigation of the relationship between the nerve secretion factors and circadian rhythm of blood pressure in female patients with climacteric hypertension

Objective To investigate the relationship between nerve-secretion factors and circadian rhythm of blood pressure in female patients with climacteric hypertension（FCH） .Methods The ambulatory blood pressure monitoring was made among 78 FCH patients and the plasma NPY、NT concentrations of the patients were determined by radioimmunoassa（RIA） .According to the results of ABPM,the patiens were divided into dipper type group and non dipper type group.Results The plasma NPY level was remarkably in positive correlation with 24haverage systolic pressure,average diastolic pressure,and average artery pressure（r=0.320,P〈0.05;r=0.297,P〈0.05;r= 0.484,P〈0.01） ,while the NT level was remarkably in negative correlation with 24haverage diastolic pressure and average artery pressure（r=-0.288,P〈0.05;r=-0.473,P〈0.01） .Conclusion The circadian rhythm of plasma NPY and NT is different in female climacteric hypertension group with the different distribution of blood pressure. NPY and NT may participate in the pathophysiological course of hypertension.Plasma NPY and NT levels,to a certain degree,can be used as one of the important indicators in the evaluation of the blood pressure changes of FCH patients with hypertension.