系统性红斑狼疮患者外周血基质金属蛋白酶-3检测及其临床意义

目的　检测系统性红斑狼疮 (SLE)患者外周血清基质金属蛋白酶 3 (MMP 3)水平并探讨其临床意义。方法　MMP 3检测采用ELISA方法。结果　SLE患者血清MMP 3水平为99 86ng/ml(中位数 ,下同 )显著高于正常对照组 2 7 82ng/ml (P <0 0 0 1)。SLE患者中 ,发生神经精神性狼疮者MMP 3水平显著高于非神经精神性狼疮患者 (P <0 0 1) ,发生狼疮肾炎者MMP 3亦明显高于无肾损害者 (P <0 0 5 ) ,而发生多发性关节炎和颊部皮疹 /光敏感患者分别与无多发性关节炎和颊部皮疹 /光敏感患者的MMP 3水平差异无显著性 (P >0 0 5 ) ;出现抗dsDNA抗体阳性、低补体C3血症、低白蛋白血症、高IgG血症及血肌酐升高者血清MMP 3水平均分别显著高于无上述表现者 (P <0 0 5 ) ,SLE患者血清MMP 3水平与SLEDAI呈正相关关系 (P <0 0 5 )。结论　SLE患者血清中MMP 3水平显著升高 ,可作为狼疮活动的参考指标之一。MMP 3参与SLE的病理生理过程 ,与SLE的某些临床检验异常表现及狼疮脑、肾等脏器损害有关

Determination of serum matrix metalloproteinase-3 in patients with active systemic lupus erythematosus

Objective To determine serum matrix metalloproteinase 3 (MMP 3) levels in patients with systemic lupus erythematosus (SLE).Methods The serum concentration of MMP 3 was determined by ELISA.Results Serum MMP 3 levels were elevated in the active SLE patients compared with healthy controls.In the SLE patients,serum MMP 3 levels in those with nervous system damage and lupus nephritis were higher than those in no nervous system damage and non nephritis,respectively,but serum MMP 3 levels in SLE with arthritis and malar rash were not increased compared with those with non arthritis and malar rash,respectively.The MMP 3 levels were significantly higher in SLE patients with the following laboratory abnormalities:anti double strand DNA antibodies,decreased C3,hypoalbuminemia,increased serum creatinine and increased serum IgG.Serum MMP 3 levels in SLE had a strong correlation with the SLEDAI ( r =0 711, P <0 05).Conclusion The elevated serum concentration of MMP 3 may be a useful marker for disease activity in patient with SLE,suggesting that it may play an important role in pathogenesis of SLE,especially in lupus brain damage and nephritis.