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The Antiplasmodial Agents of the Stem Bark of Entandrophragma Angolense (Meliaceae) |
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| Authors: | Jean Bickii Guy Raymond Feuya Tchouya Jean Claude Tchouankeu and Etienne Tsamo |
| Institution: | aInstitut de Recherches Médicales et d''Etudes des Plantes Médicinales (I.M.P.M.), Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon;bFaculty of Science, University of Yaoundé 1, P. O. Box 812 Yaoundé, Cameroon |
| Abstract: | In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane - methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7α-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 µg/ml respectively. Other compounds were moderately active. |
| Keywords: | Plasmodium falciparum Meliaceae Entandrophragma angolense Limonoids Fatty acids Triterpenoids 7α-obacunyl acetate 24-methylenecycloartenol anti-plasmodial activity |