Anti-Inflammatory and Antimicrobial Activities of Hippocratea Indica Root Bark and Poga Oleosa Fruits |
| |
| Authors: | O O Ogbole M N Ekor B B Oluremi E O Ajaiyeoba A A Gbolade M A Ayoola A A Adeyemi |
| |
| Affiliation: | 1.Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria;2.Department of Pharmacology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne campus, Ogun State, Nigeria;3.Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria;4.Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Oyo State, Nigeria |
| |
| Abstract: | The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants. |
| |
| Keywords: | Hippocratea indica Poga oleosa anti-inflammatory antimicrobial |
|
|
