Age-dependent changes in the response to staphylococcal enterotoxin B |
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Authors: | Aroeira Luiz Stark; Williams Owen; Lozano Estrella G; Martinez-A Carlos |
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Institution: | 1 Departamento de Bioquimica e Imunologia. Instituto de Ciencias Biologicas Universidade Federal de Minas Gerais Belo Horizonte, Minas Gerais, Brasil Caixa Postal
2 Centro Nacional de Biotecnologia, CSIC, Universidad Autónoma de Madrid Madrid 28049, Spain |
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Abstract: | In the present study we investigated the response of old miceto staphylococcal enterotoxin B (SEB) immunization. Old micewere susceptible to lethal toxic shock, probably mediated bytumor necrosis factor-, although lethal toxic shock was notobserved in young mice. Old mice were able to produce more IL-2and IL-4 than young mice in response to in vivo immunizationwith SEB. Vß8+CD4+ T cells of old mice expanded lessin vivo and were not deleted in response to SEB. However, inspite of the absence of clonal deletion, SEB was found to induceenergy of SEB reactive cells in old mice, as demonstrated byreduced in vitro T cell proliferation to SEB and reduced invitro IL-2 and IL-4 production. |
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Keywords: | clonal deletion interleukin old mice septic shock |
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