运动训练对大鼠骨骼肌和肝脏金属硫蛋白诱导和金属离子代谢的影响

观察了耐力游泳训练对大鼠骨骼肌和肝脏金属硫蛋白(Metallothionein，MT)诱导性的影响，以及训练大鼠力竭性游泳后，MT和锌、铜、铁、锰、钙、镁等金属离子含量的动态变化，探讨了它们之间的关系。结果显示耐力性游泳训练可使大鼠骨骼肌和肝脏MT的基础水平升高。训练大鼠力竭性游泳后，骨骼肌和肝脏中诱导合成的MT的峰值提前出现，表明运动训练可加快MT的诱导合成。MT较高的基础水平和快速的诱导合成，可能是训练促进运动恢复的生理机制之一。训练大鼠力竭性游泳后，骨骼肌锌、铜、锰和肝脏锌、铜、锰、铁的变化趋势与MT的变化趋势较为一致，表明MT可能参与了这些金属离子的代谢。MT可能通过调节金属离子代谢，在机体的运动恢复中发挥重要作用。

Effects of Exercise Training on Induction of Metallothionein and Metabolism of Metal Ions in Skeletal Muscle and Liver of Rats

In this study, the effects of endurance swim training on the induction of metallothionein (MT) as well as the dynamic changes of MT, zine, copper, iron, manganese, calcium, and magnesium in skeletal muscle and liver of the trained rats after exhaustive swim were observed . The relations between MT and the metal ions were also analyzed. The results showed that MT was elevated to higher basal level both in skeletal muscle and liver after 4 weeks of endurance swim training. The exhaustive swim- induced MT peak values both in skeletal muscle and liver of the trained rats shifted to earlier time, indicating that exercise training can result in a quicker induction and synthesis of MT. It is suggested that the higher basal level and quicker induction and synthesis of MT could be one of the physiological mechanisms by which the exercise training improves the tissue recovery after intensive exercise. The fact that changes of zinc, copper and manganese contents both in skeletal muscle and liver, and iron content in liver were paralleled roughly to those of MT implies that MT is probably involved in the metabolisms of the metal ions. MT may play an important role during tissue recovery process after exercise by regulating the trace elements and minerals.