| 兔门静脉主干内植入连续排列~（125）I粒子条的实验研究 |
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| 引用本文： | 李说,颜志平,张雯,吴林霖,刘清欣,罗剑钧,王建华.兔门静脉主干内植入连续排列~（125）I粒子条的实验研究[J].介入放射学杂志,2009,18(8):607-611. |
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| 作者姓名： | 李说 颜志平 张雯 吴林霖 刘清欣 罗剑钧 王建华 |
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| 作者单位： | 复旦大学附属中山医院放射科,上海,200032 |
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| 基金项目： | 复旦大学青年基金医院资助 |
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| 摘 要： | 目的 评价兔门静脉腔内植入连续排列125I粒子条的安全性.方法 将20只新西兰大白兔随机分成两组并编号,包括实验组(T组)和对照组(C组).实验组动物将封装在导管内连续排列的3粒125I粒子条经开腹、穿刺,悬挂固定在门静脉主干内壁.对照组仅开腹门静脉作荷包缝合.术后14、28、60和120 d分别抽血标本并行CT检查和直接门静脉造影.实验组、对照组在14、28和60 d造影后分别处死2只动物;120 d时处死剩余动物.收取门静脉主干,邻近肝、肠等组织及远处肝组织行病理检查.结果 实验组动物未发现125I粒子辐射相关的呕吐、腹泻、体重下降等症状及死亡.MDCT及DSA均显示门静脉血流通畅.病理大体标本未显示门静脉穿孔,狭窄及血栓形成,植入粒子条与管壁无粘连.实验组镜下见血管内皮细胞坏死、脱落,中膜及外膜无改变.临近125I粒子旁肝细胞坏死明显,肝右叶下角及十二指肠组织无异常.两组间血常规及肝功能比较差异无统计学意义(P>0.05).结论 连续排列125I粒子条兔门静脉管腔内植入安全、可行.
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| 关 键 词： | 125I 近距离治疗 门静脉 血管腔内的 动物实验 血管损伤 |
Implantation of the linear ~(125)I seed strand into portal venous trunk:an experimental study in rabbits |
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| LI Shui,YAN Zhi-ping,ZHANG Wen,WU Ling-ling,LIU Qing-xin,LUO Jian-jun,WANG Jian-hua.Implantation of the linear ~(125)I seed strand into portal venous trunk:an experimental study in rabbits[J].Journal of Interventional Radiology,2009,18(8):607-611. |
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| Authors: | LI Shui YAN Zhi-ping ZHANG Wen WU Ling-ling LIU Qing-xin LUO Jian-jun WANG Jian-hua |
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| Institution: | LI Shui,YAN Zhi-ping,ZHANG Wen,WU Ling-ling,LIU Qing-xin,LUO Jian-jun,WANG Jian-hua. Department of Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective To evaluate the safety of implanting 125I seed strand into portal vein in experimental rabbits. Methods Twenty New Zealand white rabbits were equally and randomly divided into experimental group (group T) and control group (group C), and all the rabbits were numbered. Three linear 125I seeds were sealed in a transparent catheter to form a seed strand. The seed strand was inserted into portal vein and rigidly suspended on the inner wall of portal vein in rabbits of group T, while only laparotomy wi... |
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| Keywords: | 125I brachytherapy portal vein intraluminal implantation experimental animal vascular injury |
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