| 高糖高脂膳食和链脲佐菌素诱导2型糖尿病模型的建立 |
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| 引用本文： | 沈亚非,徐焱成. 高糖高脂膳食和链脲佐菌素诱导2型糖尿病模型的建立[J]. 实用诊断与治疗杂志, 2006, 20(9): 649-650 |
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| 作者姓名： | 沈亚非 徐焱成 |
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| 作者单位： | 1. 漯河市中心医院内分泌科,河南省,462000
2. 武汉大学中南医院内分泌科 |
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| 摘 要： | 目的：研究高糖高脂膳食和链脲佐菌素诱导2型糖尿病大鼠模型的建立。方法：高糖高脂饲料喂养Wistar雄性大鼠4周，然后用亚致病剂量链脲佐菌素腹腔注射。结果：高糖高脂饮食4周后，大鼠出现高胰岛素血症和胰岛素抵抗，链脲佐菌素注射后大鼠出现高血糖症。结论：本研究通过饮食方法结合小剂量链脲佐菌素注射成功制备了2型糖尿病模型，并可作为研究T2DM及其并发症的理想动物模型。
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| 关 键 词： | 2型糖尿病 动物模型 大鼠 |
| 文章编号： | 1672-3457（2006）09-649-02 |
| 收稿时间： | 2006-04-14 |
| 修稿时间： | 2006-04-14 |
Type 2 diabetes mellitus induced by diets and streptozotocin in rats |
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| SHEN Yafei,XU Yancheng. Type 2 diabetes mellitus induced by diets and streptozotocin in rats[J]. Journal of Practical Diagnosis and Therapy, 2006, 20(9): 649-650 |
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| Authors: | SHEN Yafei XU Yancheng |
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| Abstract: | Objective To study the experimental type 2 diabetes mellitus animal model in rats induced by diets and streptozotocin. Methods Male rats were fed with the diet enriched with high glucose and high fat,and after 4 weeks streptozotocin was injected intraperitoneally. Results Male Wistar rats were fed with high glucose and high fat diet to induce insulin resistance, and then hyperglycemia was developed in these rats with streptozotocin which had been simulated type 2 diabetes mellitus. Conclusion The type 2 diabetic mellitus model of Wistar rats could be duplicated with diets and streptozotocin. The model is an ideal one for the study on type 2 diabetes mellitus and its complications. |
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| Keywords: | Type 2 diabetes mellitus animal model rat |
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