胃癌组织E-钙粘蛋白和β-连环素检测及临床价值

目的:探讨胃癌组织中E-钙粘蛋白(E-cad)和β-连环素(β-Cat)的表达及其临床价值。方法:免疫组化法检测85例胃癌组织和30例胃良性病变组织中E-cad和β-Cat表达。结果:胃良性病变组织中E-cad和β-Cat阳性表达率均为100%,而胃癌组织E-cad和β-Cat阳性表达率分别仅为41.2%和34.1%,两者对照均有极显著性差异(p<0.01)。随着胃癌浸润深度增加、有淋巴结转移以及分期晚者β-Cat阳性表达率愈低(p<0.05)。结论:E-cad和β-Cat在胃癌组织中表达下调。检测胃癌组织中β-Cat表达有助于在术前判断胃癌的浸润转移及TNM分期。

Significance of E-cadherin and β-catenin in gastric cancer

Objective To investigate the expression of epithelial-cadherin(E-cad) and β-catenin(β-Cat) and its significance in gastric cancer.Methods E-cad and β-Cat expression were detected in lesions from 85 gastric cancers and 30 benign gastric lesions by immunohistochemical method.ResultsAll benign lesions of stomach 100% expressed E-cad and β-Cat.The positive rate of E-cad and β-Cat in gastric cancers(41.2% and 34.1%,respectively)were significantly lower than that in benign lesions of stomach(p<0.01).The more invasion depth,lymph node metastasis and advanced stage of gastric cancer,the less the positive rate of β-Cat(p<0.05).Conclusion E-cad and β-Cat was downregulated in gastric cancer.Detection of β-Cat expression in the tissue of gastric cancer obtained by endoscopic biopsy could preoperatively evaluate the tumor invasion,metastasis and TNM stage.