Synthesis and nonthrombogenicity of polyetherurethaneurea film grafted with poly(sodium vinyl sulfonate). |
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| Authors: | Y Ito Y Iguchi T Kashiwagi Y Imanishi |
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| Affiliation: | Department of Polymer Chemistry, Kyoto University, Japan. |
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| Abstract: | Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors. |
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