心周脂肪组织体积与传统心血管疾病危险因素相关性研究

目的评价心周脂肪组织(PAT)体积与传统心血管疾病危险因素的相关性及对冠心病的诊断预测价值。方法将南京军区南京总医院2006-12-01—2010-01-31同期行64排双源CT和经皮冠状动脉造影检查临床怀疑冠心病的患者310例,进行腰围、体重指数(BMI)、空腹血生化测定。使用64排双源CT测定PAT体积,通过经皮冠状动脉造影检查明确冠心病诊断。结果 (1)冠心病患者PAT体积明显大于非冠心病患者(P<0.01);(2)男性PAT体积明显大于女性(P<0.01);(3)PAT体积与年龄、性别、BMI、腰围、原发性高血压、糖尿病、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸、纤维蛋白原有相关性(P<0.05或P<0.01);(4)Logistic逐步回归分析显示,PAT体积、BMI、腰围是影响冠心病发生的独立危险因素;(5)PAT体积诊断冠心病的ROC曲线下面积为0.65±0.04(P<0.01),明显优于腰围和BMI。结论 PAT体积与已知传统的心血管疾病危险因素和冠心病的发生有强的相关性,并且反映了多个传统危险因素的聚类效应。PAT体积对冠心病诊断的预测价值优于腰围和BMI,可作为一个新的冠心病预测指标。

Correlation between pericardial adipose tissue mass and classical cardiovascular risk factors.

Objective To investigate the correlation between pericardial adipose tissue(PAT) volume and classical cardiovascular risk factors,and to evaluate the diagnostic or predictive value of PAT as determined by dual-source CT for coronary artery disease.Methods 310 consecutive patients with suspected coronary artery disease who underwent dual-source 64-slice CT and percutaneous coronary angiography in Nanjing General Hospital of Nanjing PLA Military Command,between 1 December 2006 and 31 January 2010,were recruit...