| 男性阻塞性睡眠呼吸暂停低通气综合征血浆同型半胱氨酸变化的研究 |
| |
| 引用本文： | 王玮,孔德磊,康健. 男性阻塞性睡眠呼吸暂停低通气综合征血浆同型半胱氨酸变化的研究[J]. 中国实用内科杂志, 2011, 0(3): 198-200 |
| |
| 作者姓名： | 王玮 孔德磊 康健 |
| |
| 作者单位： | 中国医科大学附属一院呼吸疾病研究所; |
| |
| 基金项目： | 国家自然科学基金(30871136) |
| |
| 摘 要： | 目的评估男性不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与血浆同型半胱氨酸(Hcy)的关系。方法选取2008年10月至2010年12月中国医科大学附属第一医院男性OSAHS患者45例,分为轻中度组23例和重度组22例以及健康男性对照组20名,用酶联免疫吸附试验比较各组间血浆Hcy浓度。22例重度OSAHS患者在治疗1个月后再次行Hcy检测。结果OSAHS患者血浆Hcy浓度较对照组明显升高[(15.9±7.8)μmol/L对(10.0±1.2)μmol/L,P<0.01],与夜间SpO2<90%时间占总睡眠时间的百分比呈显著正相关(r=0.441,P<0.01),与夜间平均SpO2呈负相关(r=-0.393,P<0.01)。然而分组比较后,只有重度OSAHS患者Hcy浓度[(19.6±6.7)μmol/L]高于对照组(P<0.01),经治疗后虽有明显降低[(15.4±4.8)μmol/L],但仍高于对照组(P<0.01)。结论重度OSAHS可引起血浆Hcy浓度升高,与低氧程度密切相关,治疗后血浆Hcy浓度有所下降。
|
| 关 键 词： | 阻塞性睡眠呼吸暂停 同型半胱氨酸 内皮功能 |
The plasma level of homocysteine in male patients of obstructive sleep apnea and hypopnea syndrome. |
| |
| WANG Wei,KONG De-lei,KANG Jian. The plasma level of homocysteine in male patients of obstructive sleep apnea and hypopnea syndrome.[J]. Chinese Journal of Practical Internal Medicine, 2011, 0(3): 198-200 |
| |
| Authors: | WANG Wei KONG De-lei KANG Jian |
| |
| Affiliation: | WANG Wei,KONG De-lei,KANG Jian.Institute of Respiratory Diseases,First Affiliated Hospital of China Medical University,Shenyang 110001,China |
| |
| Abstract: | Objective To investigate the correlation between various degrees of male patients of obstructive sleep apnea and hypopnea syndrome(OSAHS) and plasma level of homocysteine(Hcy).Methods 45 male OSAHS patients allocated to mild-to-moderate and severe groups were matched with 20 healthy male controls.Enzyme-linked immunosorbent assay(ELISA) was used to measure Hcy in these groups.The 22 OSAHS patients in severe group were re-evaluated for plasma Hcy at one month after treatment.Results Overall,the Hcy concentra... |
| |
| Keywords: | obstructive sleep apnea homocysteine endothelial function |
| 本文献已被 CNKI 等数据库收录！ |
|
