| 活血潜阳方对高血压大鼠血压和左室心肌间质重构的影响 |
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| 引用本文： | 青淑云,符德玉,杨秀青,钱岳晟,罗海明,金露,徐邦杰.活血潜阳方对高血压大鼠血压和左室心肌间质重构的影响[J].辽宁中医药大学学报,2009(6). |
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| 作者姓名： | 青淑云 符德玉 杨秀青 钱岳晟 罗海明 金露 徐邦杰 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院心内科;武警8660部队医院内科;上海市瑞金医院心内科;上海市高血压研究所; |
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| 基金项目： | 国家自然科学基金资助项目(30572381) |
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| 摘 要： | 目的:观察活血潜阳方对自发性高血压大鼠(SHR)血压和左室心肌间质重构的影响。方法:72只SHR随机分SHR对照组、活血潜阳方组、缬沙坦组及两药合用组。20只京都Wistar大鼠(WKY)作为正常对照组。治疗前测大鼠尾动脉收缩压(SBP)、舒张压(DBP);分别于治疗7周及14周后测定SBP、DBP和左心室重量指数(LVMI),光镜观察并计算胶原容积分数(CVF)。结果:SHR的SBP、DBP、LVMI和CVF均高于同龄WKY大鼠(P<0.05或P<0.01)。活血潜阳方治疗14周可抑制SHR的SBP、DBP增高(P<0.05或P<0.01),可降低SHR的LVMI和CVF(P<0.05或P<0.01),较7W效果更明显;活血潜阳方与缬沙坦合用治疗14周可进一步降低SHR的CVF(P<0.01)。结论:长疗程(14W)的活血潜阳方治疗具有缓和的降压作用,并改善心肌间质重构,可能是其逆转高血压左室肥厚的机制。
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| 关 键 词： | 活血潜阳方 高血压 左室肥厚 心肌间质重构 大鼠 |
Effects of Huoxue Qianyang Formula on Blood Pressure and Reconstitution of Interstitial Substance of Left Ventricular in Spontaneous Hypertension Rat |
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| QING Shu-yun,FU De-yu,YANG Xiu-qing,QIAN Yue-sheng,LUO Hai-ming,XU Bang-jie.Effects of Huoxue Qianyang Formula on Blood Pressure and Reconstitution of Interstitial Substance of Left Ventricular in Spontaneous Hypertension Rat[J].Journal of Liaoning University of Traditional Chinese Medicine,2009(6). |
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| Authors: | QING Shu-yun FU De-yu YANG Xiu-qing QIAN Yue-sheng LUO Hai-ming XU Bang-jie |
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| Institution: | 1.Department of Cardiology;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine;Shanghai University of Chinese Tradition Medicine;Shanghai 200437;China;2.Department of Internal Medicine;8660 Armed Police Forces Hospital;Yining;Xinjiang 835000;3.Department of Cardiology;Ruijing Hospital;Institute of Hypertension of Shanghai;Shanghai 200025;China |
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| Abstract: | Objective:To explore the effects of Huoxue Qianyang formula on blood pressure and reconstitution of left ventricular(LV).Methods:Seventy-two SHRwere randomly devided into SHR control(SHR-C) group,Huoxue Qianyang formula(SHR-H) group,Valsartan(SHR-V) group and combination of Huoxue Qianyang formula and Valsartan(SHR-HV) group.Twenty Wistar-Kyoto(WKY) rats served for normal controls.The half of rats in every group were observed respectively for seven or fourteen weeks.Before and after treatment,the systolic a... |
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| Keywords: | Huoxue Qianyang formula Essential Hypertension Left Ventricular Hypertrophy reconstitution of myocardial interstitial substance rats |
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