| 脑缺血再灌注后大鼠氧化水平和神经功能损伤及异丙酚的影响 |
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| 引用本文： | 谭海波,于灵芝,边雯,张文嘉,张刚,张娜,石秀芳.脑缺血再灌注后大鼠氧化水平和神经功能损伤及异丙酚的影响[J].山东大学学报(医学版),2010,48(1):41-44. |
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| 作者姓名： | 谭海波 于灵芝 边雯 张文嘉 张刚 张娜 石秀芳 |
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| 作者单位： | 1. 山东大学附属济南市中心医院疼痛科,济南,250013
2. 山东大学附属省立医院麻醉科,济南,250021 |
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| 基金项目： | 山东省优秀中青年科学家科研奖励基金(2004BS03013) |
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| 摘 要： | 目的 观测大鼠脑缺血再灌注后神经损伤及血清氧化水平的变化及异丙酚的影响.方法 采用大脑中动脉线栓法制备大鼠脑缺血再灌注模型,88只大鼠随机分为假手术组(n=8)、缺血再灌注模型组(n=40)和异丙酚(100mg/kg)干预组(n=40).分别于再灌注6、24h,2、4、7d对大鼠进行神经功能损伤评分,并行梗死灶的观察及分光光度法对血清超氧化物歧化酶(SOD)、丙二醛(MDA)的检测.结果 与模型组比较,异丙酚干预组大鼠缺血再灌注后的神经功能损伤评分低,24h、2 d差异有统计学意义(P<0.05);梗死灶面积减小,MDA降低,SOD的活性升高(P<0.05).结论 异丙酚能明显提高SOD的活性,减少MDA的积聚,缩小脑梗死体积,改善脑缺血再灌注损伤后神经损伤.
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| 关 键 词： | 异丙酚 脑缺血再灌注损伤 抗氧化 神经功能损伤评分 模型 动物 |
| 收稿时间： | 2009-10-10 |
Oxidation and neurological injury in cerebral ischemia reperfusion rates and the effect of propofol |
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| TAN Hai-bo,YU Ling-zhi,BIAN Wen,ZHANG Wen-jia,ZHANG Gang,ZHANG Na,SHI Xiu-fang.Oxidation and neurological injury in cerebral ischemia reperfusion rates and the effect of propofol[J].Journal of Shandong University:Health Sciences,2010,48(1):41-44. |
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| Authors: | TAN Hai-bo YU Ling-zhi BIAN Wen ZHANG Wen-jia ZHANG Gang ZHANG Na SHI Xiu-fang |
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| Institution: | TAN Hai-bo1,YU Ling-zhi1,BIAN Wen2,ZHANG Wen-jia1,ZHANG Gang1,ZHANG Na1,SHI Xiu-fang1(1. Department of Analgesia,Jinan Central Hospital Affiliated to Sh,ong University,Jinan 250013,China,2. Department of Anesthesiology,Provincial Hospital Affiliated to Sh,ong University,Jinan 250021,China) |
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| Abstract: | Objective To study serum oxidation level and neurological injury in cerebral ischemia reperfusion rats and the influences of propofol on them. Methods Eighty-eight rats were randomly divided into three groups:the sham operation group(n=8),the cerebral ischemia reperfusion model group(n=40) and the propofol(100 mg/kg) group(n=40). Cerebral ischemia reperfusion models were established in SD rats by middle cerebral artery occlusion (MCAO) according to the advanced Zea Longa's method. The neurological deficit s... |
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| Keywords: | Propofol Cerebral ischemia and reperfusion injury Antioxidant Neurological function deficit score Model Animal |
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