早期肠内营养支持在重度慢性阻塞性肺疾病（COPD）合并营养不良患者中临床应用

目的：观察重度慢性阻塞性肺疾病（COPD）合并营养不良患者发生率，评价早期肠内营养治疗的疗效。方法112例重度COPD患者随机分为肠内营养组（EN组）、肠外营养组（PN组），均在营养支持前及营养支持1周后观察体重指数（IBM）、血清白蛋白、血红蛋白、总淋巴细胞计数、SGRQ评分。结果治疗后两组血清白蛋白、血红蛋白、淋巴细胞总数、SGRQ评分与治疗前相比有明显改善（P 〈0.05）；治疗后两组体重指数较治疗前无明显改善（P〉0.05），两组治疗前后SGRQ评分有显著差异（P 〈0.05）。结论 PN及PN均能改善重度COPD患者的营养状态，PN在临床疗效上优于PN。

Clinical application of early support therapy to patients with severe COPD accompanied malnutrition

Objective To observe the incidence of patients with severe COPD accompanied malnutrition and evaluate the effect of early venous support therapy. Methods 112 patients with severe COPD patients were randomly divided into enteral and fewer ten patients experienced septic complications（EN group） and parenteral and fewer ten patients experienced septic complications（PN group）, two groups of patients in the nutrition support and nutrition support after 1 week before the observation of body mass index（IBM）, serum albumin, hemoglobin, total lymphocyte count, SGRQ scores. Results Serum albumin, hemoglobin, total number of lymphocytes, SGRQ scores of two groups after treatment have significant differences compared with pretreatment（P 〈0.05）; Two groups of body mass index after treatment no significant improvement compared with pretreatment（P 〉0.05）. Two groups of contrast SGRQ scores before and after treatment respectively have significant differences compared with pretreatment（P 〈0.05）. Conclusion Enteral nutrition and parenteral nutrition can improve the nutritional status of patients with severe COPD, parenteral nutrition is better than that of enteral nutrition on clinical curative effect.