B超与肝纤维化指标联合检测在血吸虫病肝纤维化诊断中的临床价值

目的：分析B超与肝纤维化指标联合监测对血吸虫病肝纤维化的诊断效果及其应用价值。方法对2007-2012年收治的615例血吸虫病患者进行诊断，将金标准病理诊断为肝纤维化的患者作为病例组，其余患者为对照组，分别对两组患者进行B超、肝纤维化四项指标的检测分析。结果肝纤维化Ⅱ、Ⅲ级患者的肝纤维化指标Ⅲ型前胶原（PC-Ⅲ）、Ⅳ型胶原（IV-C）、层粘连蛋白（LN）、透明质酸（HA）的值均高于对照组，差异有统计学意义；肝纤维化I级患者与对照组肝纤维化指标PC-Ⅲ、IV-C、LN、HA的值相比无统计学差异；肝纤维化指标和B超联合检查肝纤维化敏感度为98.53%、特异度为98.27%、符合率为98.69%。结论 B超与肝纤维化指标联合监测血吸虫病肝纤维化具有良好的诊断价值。

Clinical value in the diagnosis of schistosomiasis liver fibrosis of ultrasound and liver fibrosis index joint detection

Objective Analysis ultrasound of with indicators of hepatic fibrosis diagnosis for the joint detection of schistosomiasis liver fibrosis effect and application value. Method From 2007 to 2012 treated 615 cases of schistosomiasis diagnosis, the gold standard in the pathological diagnosis of liver fibrosis in patients with as case group, the rest of the patients as control group, respectively on two groups of patients with ultrasound, four indicators of liver fibrosis for testing analysis. Result Liver fibrosis grade Ⅱ, Ⅲ liver fibrosis indexes in patients with procollagen Ⅲ（PC-Ⅲ）,COLⅣ（IV-C）, laminin（LN） and hyaluronic acid（HA） values are higher than the control group with statistical significance;Liver fibrosis in patients with grade I of liver fibrosis indexes with the control PC-Ⅲ, Ⅳ-compared to the value of C, LN and HA no comparable, there was no statistically significant difference; Indicators of hepatic fibrosis and ultrasonic examination of liver fibrosis＇s sensitivity is 94.53%, specificity is 96.27%, the coincidence rate is 96.61%. Conclusion Ultrasound is associated with indicators of hepatic fibrosis in the joint detection of schistosomiasis liver fibrosis has good diagnostic value.