氯吡格雷联合阿司匹林、阿托伐他汀治疗轻型急性脑梗死的疗效观察

目的：探讨氯吡格雷联合阿司匹林、阿托伐他汀治疗轻型急性脑梗死的临床疗效。方法将188例符合条件的轻型急性脑梗死患者随机分为治疗组96例和对照组92例，两组均给阿司匹林、阿托伐他汀等药物常规治疗，治疗组在此基础上加用氯吡格雷口服治疗；应用中国脑卒中临床神经功能缺损程度评分量表（1995）评估两组治疗前与治疗后14d、90d的功能状态，使用改良Rankin量表（MRS）评估治疗后90d两组患者功能恢复结果。结果治疗组治疗后14d及90d的临床神经功能缺损评分下降情况均明显优于对照组（P 〈0.01）；治疗后90d治疗组临床疗效优于对照组（P 〈0.01）。结论氯吡格雷联合阿司匹林、阿托伐他汀治疗轻型性性脑梗死疗效明显，可促进神经功能的恢复，改善近期预后，使用安全性高。

Clinical observation of clopidogrel combined with aspirin,atorvastatintreatment of mild acute cerebral infarction

Objective Analysis of clinical efficacy of clopidogrel combined with aspirin, atorvastatin treatment of mild acute cerebral infarction. Methods We selected 188 cases of mild acute cerebral infarction eligible patientsrandomly into treatment group 96 cases and control group of 92 cases, The two groups were given atorvastatin drugs such as aspirin, conventional treatment, the treatment group based on the use of clopidogrel oral treatment; Application of Chinese stroke clinical neural function defect score（1995） functional evaluation of two groups before treatment and after treatment14d, 90d, Using the modified Rankin scale（MRS） evaluation after two 90d of treatment group patients after stroke, functional outcome. Results After treatment, clinical neural function defect 14d and 90d score decreased obviously better than the control group（all P 〈0.01）; 90d after treatment of clinical efficacy of the treatment group than in control group（P 〈0.01）. Conclusion The combination of clopidogrel and aspirin, atorvastatin treatment of cerebral infarction was light, can promote the recovery of neurological function, improve the prognosis, high use safety.