Cell lines produced from tumors caused by virus SV 40

Summary A transplantable cellular strain, CA-SV 40-63-1, was produced from a sarcoma in a Syrian hamster induced by injection of SV 40 virus. The cellular strain formed after a prolonged lag-phase. The CA-SV 40-63-1 cultures were characterized by a marked cellular polymorphism, high mitotic activity, a tremendous number of giant mono- and polynuclear cells. The administration of cells of the CA-SV 40-63-1 strain to Syrian hamsters causes the formation of sarcomas of which the cellular composition bears a striking resemblance to that of the CA-SV 40-63-1 strain. One of such tumors gave rise to a new cellular strain, CA-SV 40-63-1 bis, which formed without the lag-phase. The cytological characteristics of the 2nd cellular strain are close to those of the CA-SV 40-63-1 strain. Certain aspects of the problem of relationships between the processes of malignization of cells in vivo and transformation of cells in vitro are also discussed.Presented by Active Member of AMN SSSR V. M. Zhdanov Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 59, No. 5, pp. 85–88, May, 1965