| 体外循环对血小板数量和功能的影响及机制 |
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| 引用本文： | 王娜,曾思思,李佳蓓,高露月,汪芳俊. 体外循环对血小板数量和功能的影响及机制[J]. 中国体外循环杂志, 2022, 0(1) |
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| 作者姓名： | 王娜 曾思思 李佳蓓 高露月 汪芳俊 |
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| 作者单位： | 川北医学院麻醉系;川北医学院附属医院麻醉科 |
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| 基金项目： | 四川省卫生健康委员会科技基金资助项目(17PJ215)。 |
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| 摘 要： | 体外循环(ECC)后大多数患者血小板数量和功能均下降。一些患者在术后由于血小板数量减少或功能异常而出现凝血功能紊乱、出血、形成血栓、延长住院时间,甚至死亡。ECC本身,以及ECC期间使用的药物等均有可能导致患者血小板数量下降或功能异常。本文就ECC后血小板变化情况和其机制进行综述讨论以期对ECC期间及术后对血小板保护提供参考,改善心脏手术患者预后。
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| 关 键 词： | 体外循环 血小板 免疫 凝血 |
Effect and mechanism of extracorporeal circulation on platelet count and function |
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| Wang Na,Zeng Sisi,Li Jiabei,Gao Luyue,Wang Fangjun. Effect and mechanism of extracorporeal circulation on platelet count and function[J]. Chinese Journal of Extracorporeal Circulation, 2022, 0(1) |
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| Authors: | Wang Na Zeng Sisi Li Jiabei Gao Luyue Wang Fangjun |
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| Affiliation: | (Department of Anesthesiology,Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China) |
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| Abstract: | The number and function of platelets decreased in most patients after extracorporeal circulation(ECC). Some patients suffer from coagulation disorders, bleeding, thrombus formation, prolonged hospital stay, and even death after surgery due to decreased platelet count or abnormal function. ECC itself, as well as the drugs used during ECC, may lead to the decrease of platelet count or abnormal function. In this article, the changes of platelets and their mechanisms after ECC were reviewed and discussed in order to provide reference for platelet protection during and after ECC and to improve the prognosis of patients undergoing cardiac surgery. |
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| Keywords: | Extracorporeal circulation Platelet Immunity Coagulation |
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