Dissemination in five French hospitals ofKlebsiella pneumoniae serotype K25 harbouring a new transferable enzymatic resistance to third generation cephalosporins and aztreonam |
| |
| Authors: | A Bure P Legrand G Arlet V Jarlier G Paul A Philippon |
| |
| Institution: | (1) Service de Bactériologie, Hôpital Claude Bernard, 75019 Paris, France;(2) Service de Bactériologie, Hôpital Henri Mondor, 94010 Créteil, France;(3) Service de Bactériologie, Hôpital Saint-Louis, 75018 Paris, France;(4) Service de Bactériologie, Hôpital Pitié-Salpêtrière, 75651 Paris, France;(5) Service de Bactériologie, CHU Cochin, 24 rue du Faubourg Sant-Jacques, 75614 Paris, CEDEX 14, France |
| |
| Abstract: | A strain ofKlebsiella pneumoniae K25 resistant to newer -lactam drugs was isolated in clusters in five hospitals in the Paris area. The MICs of ceftazidime and aztreonam ( 128 mg/l) were higher than that of cefotaxime (16 mg/l) for the strain but when measured in the presence of clavulanic acid, they were  1 mg/l. The donor strains and derivatives produced a-lactamase with a pI of 7.75–7.8 and hydrolysing activity against a wide spectrum of-lactams similar to that of SHV-2 and SHV-3, but with significant hydrolysis of ceftazidime. This new enzyme could be designated SHV-4. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
