| 丁香挥发油与氮酮对双氯芬酸钠促透作用的比较研究 |
| |
| 引用本文： | 黄冬,吴铁,林坚涛,陈广斌. 丁香挥发油与氮酮对双氯芬酸钠促透作用的比较研究[J]. 中国药房, 2008, 19(21): 1623-1625 |
| |
| 作者姓名： | 黄冬 吴铁 林坚涛 陈广斌 |
| |
| 作者单位： | 1. 广东医学院附属医院药学部,湛江市,524001
2. 广东医学院药理研究室,湛江市,524023 |
| |
| 摘 要： | 目的:比较丁香挥发油与氮酮对双氯芬酸钠的促透作用。方法:在体外透皮吸收装置上,测定不同时间双氯芬酸钠的透过量,计算稳态流量和增渗倍数,并考察其储库效应。结果:丁香挥发油和氮酮均有促进双氯芬酸钠经皮渗透的作用,当二者合用时效果更显著。丁香挥发油与氮酮单用及合用时对双氯芬酸钠的储库效应均有显著的增强作用(P<0.05或P<0.01)。结论:丁香挥发油对双氯芬酸钠具有较强大的促透作用,可望开发成为一种透皮吸收促进剂。
|
| 关 键 词： | 丁香挥发油 氮酮 双氯芬酸钠 促透作用 |
Permeation Enhancing Effect of Flos Caryophylli Volatile Oil Versus Azone on Diclofenac Sodium |
| |
| Affiliation: | HUANG Dong, CHEN Guang-bin,WU Tie, LIN Jian-tao(1.Dept.of Pharmacy, Guangdong Medical College Affiliated Hospital, Zhanjiang 524001, China;2.Research Room of Pharmacology, Guangdong Medical College, Zhanjiang 524023, China) |
| |
| Abstract: | OBJECTIVE： To evaluate the permeation enhancing effect of Flos Caryophylli volatile oil versus azone on diclofenac sodium. METHODS： Percutaneous absorption experiment was performed on the apparatus of isolated skin, and the penetrated amounts of diclofenac sodium at different time were measured, then the steady - state flux and enhancing rate were calculated, and the deposit effect of diclofenac sodium was investigated.RESULTS： Flos Caryophylli volatile oil and azone all had promotion effect on percutaneous absorption of diclofenac sodium,especially when they used in combination.Used either in combination or alone, they all had remarkable enhancement property on deposit effect of diclofenac sodium（P〈 0.05 or P〈 0.01）. CONCLUSION： Flos Caryophylli volatile oil is expected to become a skin penetration enhancer for its relative powerful promotion effect. |
| |
| Keywords: | Flos Caryophylli volatile oil Azone Diclofenac sodium Permeation enhancing effect |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
