| 牛磺酸对阿霉素所致大鼠心肌线粒体损伤的影响 |
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| 引用本文： | 张晓丹,蔡瑞雪,吕高照,曲彩霞. 牛磺酸对阿霉素所致大鼠心肌线粒体损伤的影响[J]. 中成药, 2011, 33(2): 218-221 |
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| 作者姓名： | 张晓丹 蔡瑞雪 吕高照 曲彩霞 |
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| 作者单位： | 1. 哈尔滨商业大学药学院,黑龙江哈尔滨,150076
2. 哈尔滨市红十字医院,黑龙江哈尔滨,150076 |
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| 摘 要： | 目的:研究牛磺酸(Tau)对阿霉素(Adr)所致大鼠心肌线粒体损伤的影响.方法:将Tau灌胃于Adr所致心肌线粒体损伤的40只大鼠,采用透射电镜对大鼠心肌线粒体的损伤情况进行观察;用激光共聚焦显微镜观测心肌细胞内的Ca23浓度;以Rhodamine 123为荧光探针,用荧光分光光度计测定心肌线粒体悬液的荧光强度反应线粒体膜电位变化.结果:Adr累积用量达到20 mg/kg可致大鼠心肌线粒体损伤,Ca2+浓度增加,线粒体膜电位降低.Tau高、中剂量组(400mg/kg、200 mg/kg)可减轻心肌细胞超微结构的损伤,减轻钙超载和升高线粒体膜电位.结论:Tau能明显改善Adr所致大鼠心肌线粒体损伤,对Adr心脏毒性具有保护作用.
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| 关 键 词： | 牛磺酸 线粒体损伤 阿霉素 |
Effect of tauine on adriamycin-induced damage to myocardial mitochondria in rats |
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| ZHANG Xiao-dan , CAI Rui-xue , L Gao-zhao , Q Cui-xia. Effect of tauine on adriamycin-induced damage to myocardial mitochondria in rats[J]. Chinese Traditional Patent Medicine, 2011, 33(2): 218-221 |
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| Authors: | ZHANG Xiao-dan CAI Rui-xue L Gao-zhao Q Cui-xia |
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| Affiliation: | ZHANG Xiao-dan1,CAI Rui-xue1,L Gao-zhao1,Q Cui-xia2(1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;2.Harbin Red Cross Hospital,Harbin 150076,China) |
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| Abstract: | AIM:To study the effect of taurine on adriamycin-induced damage to myocardial mitochondria in rats.METHODS: Forty rats were given intraperitoneal injection of adriamycin(Adr) to induce the damage to myo-cardial mitochondria.After continuous ig of taurine(Tau),myocardial ultrastructure was observed in the five experimental groups(8 rats per group) with electron microscope,concentraction of Ca2 + in cardiac muscle cell was measured by laser scanning cofocal microscope.Rhodamine 123 as the probe of fluorescenc... |
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| Keywords: | taurine damage to mitochondria adriamycin |
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