CD40-CD40L在儿童过敏性紫癜发病机制中的作用研究

目的探讨CD40-CD40L存儿童过敏性紫癜发病机制中的作用。方法研究对象为30例HSP患儿，正常对照组30例，应用流代细胞术检测其外周血单个核细胞中CD40－CD40L的表达情况，并观察实验组治疗前后CD40-CD40L的表达有无差异，结果与对照组比较，CD40L表达明妙增高，且治疗前表达高于治疗后（P〈0．05），CD40表达增高，但与对照组及治疗前后比较差异均无显著性（P〉0．05）。结论HSP患儿外周血单个核细胞CD40L表达增高，且治疗前离于治疗后，表明其在HSP患儿免疫紊乱发病机制中可能起着重要作用。

The Effect of CD40 and CD40L in the Pathogenesis of Childhood HenochSchonlein Purpura

Objective To investigate the expression of CO-stimulatory molecules CD40 and CD40L in peripheral blood mononuclear cells of patients with childhood Henoch-Schonlein purpura and to explore Iheir possible roles in the disease.Methods The experimenlal group included 30 HSP patients, and the control gronp included 30 heahhy children.Applying flow cytometry to semiquantilaliw, ly analyze CD40-CD40L expression in peripheral blood mononuclear c.ells from HSP patients and normal controls.Moreover, observed if there were differenc.e between prior treatment group and post-trealment group.Results Compared with controls, the expression of CI）40L were higher in prior treatment group and post-treatment group （ P 〈 0.05 ）, the expression of CD40 were higher, but the dift〉rence have no significance （ P 〉 0.05 ）. The expression of CD40L were higher in prior treatment group than post-treatmeut group （ P 〈 0.05 ） .Conclusion The expression of CD40L were higher, and in prior treatment group than post-treatment group.The abnormal expressinn of CD40L may play an important role in the development of HSP of children.