| 甲氧滴滴涕对大鼠精子顶体酶活性的影响 |
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| 引用本文： | 刘伏祥,杨静,文建国,黄河,陈庆林.甲氧滴滴涕对大鼠精子顶体酶活性的影响[J].实用预防医学,2006,13(3):493-494. |
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| 作者姓名： | 刘伏祥 杨静 文建国 黄河 陈庆林 |
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| 作者单位： | 1. 中南大学湘雅医学院组织学与胚胎学教研室,湖南,长沙,410013;湖南益阳卫校解剖与组织胚胎学教研室
2. 中南大学湘雅医学院组织学与胚胎学教研室,湖南,长沙,410013 |
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| 基金项目： | 湖南省自然基金（01JJY2091） |
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| 摘 要： | 目的观察甲氧滴滴涕(methoxychlor,MXC)对雄性大鼠精子顶体酶活性的影响,以探讨其生殖毒性的可能机理。方法在精子悬液中加入不同浓度的MXC,以改良的Kennedy法分别测定不同浓度MXC作用下的精子顶体酶活性。结果与对照组比较,MXC作用后的各组精子顶体酶活性明显降低,且降低幅度与MXC的作用浓度有关。结论MXC对大鼠精子顶体酶活性具有明显的抑制作用。
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| 关 键 词： | 顶体酶 甲氧滴滴涕 精子 |
| 文章编号： | 1006-3110（2006）03-0493-02 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006年3月6日 |
Effects of Methoxychior on Acrosomal Enzyme Activities of Spermatozoa of Male Rats |
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| LIU Fu - xiang, YANG Jing, WEN Jian - guo ,et al..Effects of Methoxychior on Acrosomal Enzyme Activities of Spermatozoa of Male Rats[J].Practical Preventive Medicine,2006,13(3):493-494. |
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| Authors: | LIU Fu - xiang YANG Jing WEN Jian - guo |
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| Institution: | Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China |
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| Abstract: | Objective To investigate the effects of methoxychlor (MXC) on acrosomal enzyme activities of spermatozoa of male rats. Method Addtion of methoxychlor in different concentrations into the sperm suspension, the acrosin activities were measured by the improved Kennedy method. Results Compared with the control group, the sperm acrosin activities in each group treated with MXC decreased significantly, which were dependent with the concentration of MXC. Conclusions MXC has obvious dose-dependent inhibitive effects on the acrosin activities of spermatozoa of male rats. |
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| Keywords: | Acrosomal enzyme Methoxychlor Spermatozoon |
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