ER、PR、CerbB-2、p53和nm23蛋白在乳腺癌中的表达及其意义

目的：探讨ER、PR、Cerb—B-2、P53、nm23基因在乳腺癌中的表达与转移及预后的关系。方法：采用免疫组织化学（SP法）对乳腺癌ER、PR、Cerb-B-2、P53、nm23的表达进行检测。结果：ER、PR、Cerb—B-2、P53、nm23阳性率分别为48．2％、53。5％、68．4％、51．8％、71．1％。Cerb—B-2和P53与肿瘤临床分期和淋巴结转移呈正相关，差异有统计学意义（P〈0．01），与患者年龄无显著相关性。ER、nm23基因蛋白的表达与临床分级、淋巴结转移呈负相关，差异有统计学意义（P〈0．05），而与患者年龄无显著相关性。结论ER、PR、Cerb—B-2、P53、nm23基因参与乳腺癌的发生发展过程；联合检测对预测乳腺癌淋巴结转移及判断预后有重要意义。

Expression of Cerb-B-2,P53and nm23in Primary Breast Carcinoma

Objective To study the expression of oncogenes ER, PR, Cerb-B-2, P53, nm23, and the relationship of the genes with metastasis and prognosis in patients with primary breast carcinoma. Methods The expression of ER, PR, Cerb-B-2, P53, nm23was detected by immunohistochemical （s-p methods） in 114 cases of breast carcinoma. Results The positive expression of ER,PR,Cerb-B-2,P53,nm23were48.2% ,53.5% ,68.4% ,31.8% ,71.1%.The expression of Cerb-B-2, P53 were positively correlated with TNM stage and lymph node metastasis （P〈0.01）, but did nat relate to age; ER, nrn23 was negatively correlated with TNM stage and lymph node metastasis, and did not relate to age. Conclusion Oncogenes ER,PR,Cerb-B-2,P53,nm23 may play an important role in the development and progression of beast carcinoma.The combined detection of Cerb-B-2, P53and nm23 geneproleins has positive effects on predicting the lymph node metastasis and the prognosis of breast carcinoma.