精神分裂症和抑郁症伴焦虑障碍的研究

目的 了解精神分裂症和抑郁症住院病人与焦虑障碍的共病发生率及相关因素分析。方法 住院精神分裂症病人41例和抑郁病人40例，用简明精神病量表（BPRS）、Hamilton抑郁量表（HAMD）、Hamilton焦虑量表（HAMA）、Liebowitz社交焦虑量表（LSAS）进行评定。结果 精神分裂症病人焦虑障碍的共病率为29．26％，抑郁症与焦虑障碍的共病率为50L。LSAS与HAMA呈正相关（r=0.465)。有关精神分裂症和抑郁症病人共病焦虑障碍经多元逐步回归可排除药源性焦虑。结论 对精神分裂症和抑郁症共患焦虑障碍应引起临床高度重视。

A comorbidity study of anxiety disorders in patients with schizophrenia and with depression

Objectives: The aims were to explore comorbidities of anxiety disorders in patients with schizophrenia and with depression. Method: Forty-one inpatients with schizophrenia and 40 depressed in-patients were selected and assessed by the Brief Psychiatric Rating Scale (BPRS). Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (KAMA), Liebowitz Social Anxiety Scale (LSAS), and they were rediagnosed by the DSM-N criteria of anxiety disorders. Results: The comorbidity rate of anxiety disorder in schizophrenia was 29. 26% and was 50% in depression. The common comorbidity subtypes of anxiety disorders in schizophrenia were social anxiety disorder (SAD. 24. 34%), generalized anxiety disorder (GAD. 19. 50%), obsessive-compulsive disorder (OCD, 9. 75%) and in depressed group, were SAD (37. 75%), GAD (35%) and OCD (12. 5%). The logistic analysis showed that the anxiety symptoms in schizophrenic and depressed patients were not associated with antipsychotic and antidepressant treatments. Conclusion: The results suggest that the comorbid anxiety disorder is quite common in schizophrenic and depressed inpatients and the clinicians need to gain more insight into it.