| 云南人亚甲基四氢叶酸还原酶基因型多态性与乳腺癌易感性的关联 |
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| 引用本文： | 阚祥绪,邹天宁,吴瑕玉,汪旭.云南人亚甲基四氢叶酸还原酶基因型多态性与乳腺癌易感性的关联[J].肿瘤防治研究,2007,34(9):716-718. |
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| 作者姓名： | 阚祥绪 邹天宁 吴瑕玉 汪旭 |
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| 作者单位： | 1. 云南师范大学生命科学学院,昆明,650092
2. 昆明医学院第三附属医院 |
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| 基金项目： | 国家自然科学基金;云南省自然科学基金 |
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| 摘 要： | 目的亚甲基四氢叶酸还原酶(MTHFR)是叶酸代谢的关键性酶,其催化作用决定了DNA甲基化与DNA合成之间的平衡。MTHFR基因多态性可能会影响叶酸代谢结局,从而构成肿瘤风险因子。研究分析了MTHFR各基因型在云南籍乳腺癌人群和正常人群中的分布差异,初步探索了MTH-FR多态性与乳腺癌易感性之间的关系。方法以多重PCR-RFLP技术,对125例云南籍乳腺癌患者和103例正常人群MTHFR677位点1298位点多态性进行筛查。结果未发现MTHFRC677T和A1298C基因型频率在乳腺癌和对照样本之间存在显著差异。结论在目前样本条件下,上述两个MTHFR位点基因型多态性与云南籍人群的乳腺癌易感性之间无明显相关性。
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| 关 键 词： | 亚甲基四氢叶酸还原酶基因多态性 乳腺癌易感性 多重PCR-RFLP |
| 文章编号： | 1000-8578（2007）09-0716-03 |
| 收稿时间： | 2006-8-15 |
| 修稿时间： | 2006-08-15 |
Association between MTHFR Genotype Polymorphism and Breast Cancer Susceptibility in Human Population from Yunnan |
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| KAN Xiang-Xu,ZOU Tian-Ning,WU Xia-Yu,WANG Xu.Association between MTHFR Genotype Polymorphism and Breast Cancer Susceptibility in Human Population from Yunnan[J].Cancer Research on Prevention and Treatment,2007,34(9):716-718. |
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| Authors: | KAN Xiang-Xu ZOU Tian-Ning WU Xia-Yu WANG Xu |
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| Institution: | 1. School of Life Sciences, Yunnan Normal University, Kunming 650092, China; 2. Third Affiliated Hospital of Kunming Medical College |
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| Abstract: | Objective Background &; Objective Methylenetetrahydroflate reductase gene (MTHFR) encodes MTHFR which is critical for folic acid metabolism.The polymorphisms of MTHFR may affect the outcome of folic acid metabolism. The research aimed at comparing the distribution of different MTHFR genotypes between breast cancer cases(n=125) and controls(n=103) in Yunnan, and exploring the possible implication between MTHFR polymorphism and breast cancer susceptibility. Methods Multiple polymerase chain reaction-RFLP was e... |
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| Keywords: | MTHFR polymorphism Breast cancer susceptibility Multiple polymerase chain reaction-restriction fragment length polymorphism |
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