缬沙坦联合贝那普利治疗肾性高血压的临床疗效

目的 观察缬沙坦与贝那普利联合用药和氨氯地平与贝那普利联合治疗肾性高血压的临床疗效比较.方法 60例患者随机分为两组：观察组（30例）予缬沙坦每次80 mg,每日一次,贝那普利每次10 mg,每日一次;对照组（30例）予贝那普利每次10 mg,每日一次,氨氯地平每次5 mg,每日一次;疗程共2个月,观察治疗结果并进行比较.结果 两组治疗后血压均明显下降（P＜0.01）,观察组下降幅度大于对照组,差异有统计学意义（P＜0.05）.两组治疗后24 h尿蛋白定量明显减少,Scr显著降低,差异有统计学意义（P＜0.05）.观察组24h尿蛋白改善比对照组明显,差异有统计学意义（P＜0.05）;而在血肌酐方面,观察组变化幅度大于对照组,差异无统计学意义（P＞0.05）.结论 ACEI＋ARB联合用药,除有效控制肾性高血压外,在肾脏保护方面强于应用ACEI＋CCB.

Clinical curative effect of valsartan combined with benazepril on renal hypertension

Objective To compare the difference in the clinical curative effect of benazepril combined with valsartan or amlodipine in the treatment of renal hypertension. Methods The 60 patients with renal hypertension were randomly divided into the observation group （30 cases） and the control group （30 cases）. The former was given valsartan 80mg and benazepril 10mg once a day. The latter was given amlodipine 5rag and benazepril 10 mg once a day. The clinical curative effect of the two groups was observed and compared after 2 months. Results The blood pressure in the two groups after treatment all decreased significantly （P〈0.01）. the observation group dropped greater than the control group, the difference was statistically significant （P〈0.05）. The quantity of 24-hour urine protein excretion and serum creatinine in the two groups decreased significantly after treatment., the difference was also statistically significant （P〈0.05）. The improvement of 24-hour urine protein in the observation group was better than in the control group obviously, the difference was statistically significant （/9〈0.05）. In respect of serum ereatinine, the observation group varied than the control group, but the difference no statistical significance （P〉0.05）. Conclusion ACEI combined with ARB can effectively control the renal hypertension. In addition, they are stronger than ACEI and CCB in the protection of renal function.