静脉注射丙种球蛋白治疗极低出生体重儿肺炎的疗效观察

目的 探讨静脉注射丙种球蛋白治疗极低出生体重儿肺炎的疗效.方法 入选病例为2011年2月～2012年2月在我院就诊的极低出生体重儿肺炎30例,另选择同期行常规治疗的26例极低出生体重儿肺炎患儿作为对照组,比较两组患儿治疗后的疗效及两组患儿住院期间临床观察指标的变化情况,如喂养不耐受、恢复出生体重时间、胎粪排空时间的变化情况,并发症（消化道出血、高胆红素血症、低血糖、窒息、贫血、呼吸暂停、休克）.结果 观察组显效率达40.0％,无效率23.3％,总有效率达76.7％;对照组显效率34.6％,无效率42.3％,总有效率达57.7％,明显低于观察组,说明观察组的疗效明显优于对照组（P＜0.05）.观察组喂养不耐受率25％,明显少于对照组,差异具有统计学意义（P＜0.05）;观察组患儿恢复出生体重时间、胎粪排空时间均分别明显短于对照组,差异具有统计学意义（P＜0.05）.两组患儿治疗期间均出现窒息、贫血、呼吸暂停、休克、消化道出血等并发症.其中观察组并发症发生率为33.3％,对照组并发症的发生率为50.0％,观察组的并发症明显少于对照组,差异具有统计学意义（P＜0.05）.结论 静脉注射丙种球蛋白治疗极低出生体重儿肺炎疗效显著,能明显改善患儿的临床症状、缩短住院时间,并发症少,值得推广和应用.

The efficacy of intravenous gamma globulin in treatment of low birth weight children with premature

Objective To investigate the efficacy of intravenous gamma globulin in treatment of low birth weight chil- dren with premature. Methods From February 2011 to February 2012 in our hospital, selected 30 cases with very low birth weight preterm children as observation and another selected concomitant conventional therapy 26 VLBWI chil- dren as a control group,after treatment,the efficacy and clinical observation during hospitalization indicators of changes in conditions, such as pulmonary tales disappeared cooling time,hospitalization time before and after treat- ment of IgG changes, complications were compared between two groups. Results The effective rate of the observation group was 40.0%,inefficiency was 23.3% ,the total effective rate of the observation group was 76.7% ,the efficiency of the control group was 34.6%,inefficiency rate was 42.3% ,total effective rate was 57.7% ,was significantly lower than the observation group （P 〈 0.05）.Observation group feeding intolerance rate of was 25% ,was significantly less than the control group （P 〈 0.05）;Observation group＇s birth weight infants recovery time, meconium emptying times were signif- icantly shorter than the control group （P 〈 0.05）.Two groups of children were suffocation during treatment, anemia, ap- nea,shock,gastrointestinal bleeding and other complications.Complications occurred in which the observation group was 33.3%,the incidence of complications of in the control group was 50.0% with significant difference （P〈0.05）. Conclusion Intravenous gamma globulin treatment of premature low birth weight children has a significant effect, can significantly improve the clinical symptoms in children,shorter hospital stays,fewer complications,should be promoted and applied.