结缔组织病的肺功能及血气变化

目的 研究结缔组织病（CTD）患者的肺功能及血气分析变化,为CTD患者侵及肺部的及早发现及预后评估提供依据.方法 测定70例CTD患者的肺通气功能、弥散功能和动脉血气,并与健康体检组对比分析.结果 多数CTD患者肺功能改变,主要表现为弥散功能障碍、限制性通气功能障碍、小气道功能改变.其中弥散功能改变（DLCO）异常49例（49/70）.结论 CTD患者中弥散功能改变最为显著,是较敏感的肺功能指标.肺功能及动脉血气分析检查,既可以作为早期的诊断依据,也可以作为临床治疗的客观凭证,应为CTD患者的常规检查项目.

To study pulmonary function and blood gas analysis in connective tissue diseases

Objective To study the pulmonary function and blood gas changes in patients with connective tissue dis- ease（CTD）. Methods The pulmonary function and blood gas changes of 70 patients with CTD were measured and the data were compared with that of the control group. Results Most CTD patients＂ pulmonary function change, mainly characterized by diffuse dysfunction,restrictive ventilatory dysfunction and small airway function change, diffuse dys- function （DLCO） in 49 cases （49/70）. Conclusion Diffuse dysfunction of the CTD patients function change is most significant,was a sensitive index of pulmonary function. Pulmonary function and arterial blood gas analysis can be used as a early diagnosis and an objective evidence in clinical treatment. So they should be used as routine inspection projects in CTD patients