丁苯酞软胶囊联合高压氧治疗血管性痴呆临床疗效观察

目的评价丁苯酞软胶囊联合高压氧治疗血管性痴呆的疗效及安全性。方法80例血管性痴呆患者随机分成治疗组和对照组，各40例。两组均使用高压氧治疗1次/d，治疗组在上述治疗的基础上联合应用丁苯酞软胶囊0．2g，3次/d，治疗前及治疗60d后应用简易智力状态检查量表（MMSE）和Barthel指数评分评定疗效。结果疗程结束时，治疗组总有效34例，对照组总有效26例，两组比较，差异有统计学意义（P〈0．05）。治疗后患者MMSE评分及Barthel指数评分较前明显增加，治疗组增加更明显，与对照组比较，差异有统计学意义（P〈0．05）。结论丁苯酞软胶囊联合高压氧治疗血管性痴呆可明显改善患者智能障碍和生活能力，安全性好，优于单用高压氧治疗。

Clinical effect of butylphthalide soft capsules combined with hyperbaric oxygen in the treatment of vascular dementia

Objective To evaluate the safety and efficacy of butylphthalide soft capsules combined with hyperbaric oxygen in the treatment of vascular dementia. Methods A total of 80 patients with vascular dementia were randomly divided into treatment group and control group, each of 40 eases. The two groups were all treated with hyperbaric oxy- gen 1 time a day, the treatment group based on the treatment of combined application of butylphthalide soft capsules 0.2 g, 3 times a day. Before and 60 days after treatment application scale simple mental state examination （MMSE） and Barthel index seore evaluation of curative effect. Results By the end of the course, the total effective number was 34 cases in the treatment group, the total effeetive number was 26 eases in the control group, the differences were statisti- cally significant （P〈0.05）. After treatment, MMSE scores and Barthel index scores were significantly increased. The treatment group increased significantly, with statistically significant difference compared with the control group （P〈0.05）. Conclusion Butylphthalide soft capsule combined with hyperbaric oxygen treatment of patients with vascular dementia could obviously improve intelligence disorder and living ability, security, superior to hyperbaric oxygen alone.