CXCL14和EGFR 在胃癌组织中的表达及其临床意义*

目的:探讨趋化因子CXCL14和表皮生长因子受体（epidermal growth factor receptor ，EGFR）在胃癌中的表达及与临床病理特征间的关系。方法:收集2014年3 月至2015年12月武警后勤学院附属医院手术切除胃癌标本121 例及其癌旁非肿瘤胃黏膜62例和异体非肿瘤胃黏膜60例，采用免疫组织化学法分别检测CXCL14和EGFR 的表达。结果:胃癌组织中CXCL14和EGFR 阳性表达率分别为80.17% 和48.76% ，均显著高于癌旁非肿瘤胃黏膜和异体非肿瘤胃黏膜，差异均具有统计学意义（均P < 0.01）；CX?CL14表达与胃癌浸润深度、分化程度和临床分期有关，差异均具有统计学意义（均P < 0.05）；EGFR 表达与胃癌分化程度、淋巴结转移和临床分期有关，差异均具有统计学意义（均P < 0.05）。 Spearman 相关分析显示，胃癌中CXCL14的表达与EGFR 呈正相关（r s = 0.195，P < 0.05）。结论:在胃癌中CXCL14异常表达可能与胃癌的发生发展有关，与EGFR 表达呈正相关，推测二者在胃癌发生发展过程中有一定协同作用。 

Expression and clinical significance of CXCL14 and EGFR in human gastric cancer

Objective:To investigate the expression of C-X-C chemokine ligand-14 (CXCL14) and epidermal growth factor receptor (EG-FR) in human gastric cancer and to analyze the relationship of CXCL14 with clinicopathological features. Methods:The expression of CXCL14 and EGFR was detected by Immunohistochemical SP method in 121 cases of gastric cancer tissue, 62 cases of the adjacent non-tumor gastric mucosa, and 60 cases of allogeneic non-tumor gastric mucosa. Results:The positive rates of CXCL14 and EGFR expres-sion were 80.17%and 48.76%in gastric cancer, respectively, and both were significantly higher in the adjacent non-tumor gastric mu-cosa and allogeneic non-tumor gastric mucosa. The differences were significant (P<0.01). Overexpression of CXCL14 was closely corre-lated with the depth of cancer invasion, differentiation, and clinical stage, and the differences were significant (P<0.05). Overexpres-sion of EGFR was correlated with cancer differentiation, lymph node metastasis, and clinical stage. The differences were significant (P<0.05). Based on the Spearman correlation analysis, the expression of CXCL14 and EGFR in gastric cancer was positively correlated (rs=0.195, P<0.05). Conclusion:Abnormal CXCL14 expression in gastric cancer may be associated with the occurrence and development of gastric cancer. CXCL14 expression is positively correlated with EGFR expression, suggesting that the two have a synergistic effect in gas-tric cancer development.