CXCL14和EGFR 在胃癌组织中的表达及其临床意义* |
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引用本文: | 杨雪,何滔,时丽芳,郑淑芳. CXCL14和EGFR 在胃癌组织中的表达及其临床意义*[J]. 中国肿瘤临床, 2016, 43(19): 860-864. DOI: 10.3969/j.issn.1000-8179.2016.19.786 |
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作者姓名: | 杨雪 何滔 时丽芳 郑淑芳 |
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作者单位: | 作者单位:①锦州医科大学武警后勤学院附属医院研究生培养基地(天津市300162);②武警后勤学院附属医院病理科 |
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基金项目: | 本文课题受天津市应用基础及前沿技术研究计划面上项目(编号11JCYBJC13000) |
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摘 要: | 目的:探讨趋化因子CXCL14和表皮生长因子受体(epidermal growth factor receptor ,EGFR)在胃癌中的表达及与临床病理特征间的关系。方法:收集2014年3 月至2015年12月武警后勤学院附属医院手术切除胃癌标本121 例及其癌旁非肿瘤胃黏膜62例和异体非肿瘤胃黏膜60例,采用免疫组织化学法分别检测CXCL14和EGFR 的表达。结果:胃癌组织中CXCL14和EGFR 阳性表达率分别为80.17% 和48.76% ,均显著高于癌旁非肿瘤胃黏膜和异体非肿瘤胃黏膜,差异均具有统计学意义(均P < 0.01);CX?CL14表达与胃癌浸润深度、分化程度和临床分期有关,差异均具有统计学意义(均P < 0.05);EGFR 表达与胃癌分化程度、淋巴结转移和临床分期有关,差异均具有统计学意义(均P < 0.05)。 Spearman 相关分析显示,胃癌中CXCL14的表达与EGFR 呈正相关(r s = 0.195,P < 0.05)。结论:在胃癌中CXCL14异常表达可能与胃癌的发生发展有关,与EGFR 表达呈正相关,推测二者在胃癌发生发展过程中有一定协同作用。
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关 键 词: | 胃癌 CXCL14? EGFR? 免疫组织化学 |
收稿时间: | 2016-07-05 |
Expression and clinical significance of CXCL14 and EGFR in human gastric cancer |
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Affiliation: | 1Postgraduate Training Basement of Jinzhou Medical University, The Affiliated Hospital of Logistics University of Chinese Armed Police Forces (PAP), Tianjin 300162, China; |
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Abstract: | Objective:To investigate the expression of C-X-C chemokine ligand-14 (CXCL14) and epidermal growth factor receptor (EG-FR) in human gastric cancer and to analyze the relationship of CXCL14 with clinicopathological features. Methods:The expression of CXCL14 and EGFR was detected by Immunohistochemical SP method in 121 cases of gastric cancer tissue, 62 cases of the adjacent non-tumor gastric mucosa, and 60 cases of allogeneic non-tumor gastric mucosa. Results:The positive rates of CXCL14 and EGFR expres-sion were 80.17%and 48.76%in gastric cancer, respectively, and both were significantly higher in the adjacent non-tumor gastric mu-cosa and allogeneic non-tumor gastric mucosa. The differences were significant (P<0.01). Overexpression of CXCL14 was closely corre-lated with the depth of cancer invasion, differentiation, and clinical stage, and the differences were significant (P<0.05). Overexpres-sion of EGFR was correlated with cancer differentiation, lymph node metastasis, and clinical stage. The differences were significant (P<0.05). Based on the Spearman correlation analysis, the expression of CXCL14 and EGFR in gastric cancer was positively correlated (rs=0.195, P<0.05). Conclusion:Abnormal CXCL14 expression in gastric cancer may be associated with the occurrence and development of gastric cancer. CXCL14 expression is positively correlated with EGFR expression, suggesting that the two have a synergistic effect in gas-tric cancer development. |
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Keywords: | gastric cancer CXCL14 EGFR immunohistochemistry |
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