人源性肺癌组织移植瘤模型的研究进展

人源性肺癌组织移植瘤模型（patient-derived xenografts ，PDX ）是指将肺癌患者的肿瘤组织移植于免疫缺陷鼠进行增殖传代，传代的肺癌组织高度保存肿瘤生长所处的微环境，且保留原发肺癌组织的生物学、组织病理学特征以及肿瘤标志物等，是一种理想的模拟人体内环境的动物模型。该模型对肿瘤临床前期评估、抗肿瘤药物疗效评价、分析生物标志物等有重要意义，为肺癌的个体化治疗研究带来了新方向。

Research progress on patient-derived xenograft models of lung cancer

Patient-derived xenograft models (PDXs) of lung cancer are obtained by directly implanting lung cancer tissue fragments in-to immunocompromised mice. The implanted tumor fragments can be proliferated and passaged in these mice models. The PDXs maintain the tumor microenvironment, histological and pathological characteristics, and tumor biomarkers of the original tumor tis-sues. The PDX also offers an ideal mice model that mimics the human tumor microenvironment. These models have important roles in the pre-clinical evaluation of cancer, the assessment of anti-tumor drug responses, and the analysis of biomarkers. These models also present a new direction for the individualized therapy of lung cancer patients.