| Sprouty 在肿瘤中的研究进展 |
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| 引用本文： | 王珂,王国兴.Sprouty 在肿瘤中的研究进展[J].中国肿瘤临床,2016,43(8):358-360. |
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| 作者姓名： | 王珂 王国兴 |
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| 作者单位： | 作者单位:天津医科大学肿瘤医院妇科肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市300060) |
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| 摘 要： | Sprouty 蛋白是受体酪氨酸激酶（receptor tyrosine kinase ，RTK ）等信号通路的抑制因子。Sprouty 蛋白家族在多种肿瘤组织中表达降低，导致RTK 等信号通路失去正常的抑制，造成肿瘤细胞异常增殖，从而促进肿瘤的发生及发展，因而Sprouty 成为当前肿瘤靶向治疗的研究热点。本文就Sprouty 与肿瘤发生、发展关系及其在肿瘤中的研究进展进行综述。
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| 关 键 词： | Sprouty 蛋白? 信号通路 肿瘤 |
| 收稿时间： | 2016-02-14 |
Research progress on Sprouty protein in tumor |
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| Institution: | Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Treatment, Tianjin 300060, China |
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| Abstract: | The Sprouty protein can inhibit cel proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells, such as receptor tyrosine kinase signaling pathway. The Sprouty protein, which is often associated with abnormal cell proliferation and transformation, is down-regulated in many tumors, stimulating the initiation and progression of tumors. The Sprouty protein exhibits potential for developing effective treatment against cancer. This paper reviews research progress on Sprouty protein in tumor. |
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| Keywords: | Sprouty protein signaling pathway tumor |
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