| Rad51C 在DNA 损伤修复中的研究进展* |
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| 引用本文： | 丁新敏,陈秀丽(综述),王平(审校). Rad51C 在DNA 损伤修复中的研究进展*[J]. 中国肿瘤临床, 2016, 43(18): 830-833. DOI: 10.3969/j.issn.1000-8179.2016.18.502 |
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| 作者姓名： | 丁新敏 陈秀丽(综述) 王平(审校) |
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| 作者单位： | 作者单位:①天津海滨人民医院肿瘤科(天津市300280);②天津医科大学肿瘤医院放疗科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室 |
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| 基金项目： | 本文课题受国家自然科学基金(编号81372518)资助@@@@This study was supported by the National Natural Science Foundation of China (81372518) |
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| 摘 要： | 细胞毒性物质及电离辐射等易致细胞DNA 损伤，真核生物中DNA 双链断裂（double strand breaks，DSBs）修复的主要通路是同源重组（homologous recombination，HR）。 Rad51C 蛋白作为HR通路的关键因子，其表达异常可致DNA 损伤修复的失调，引起基因组的不稳定，最终导致肿瘤的发生发展。近年来随着对Rad51C 基因的研究，发现Rad51C 可能会成为恶性肿瘤治疗的潜在靶点。本文就Rad51C 在DNA 损伤修复及放疗中作用的研究进展进行综述。
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| 关 键 词： | 肿瘤 基因 DNA 损伤 重组/ 同源重组 Rad51C |
| 收稿时间： | 2016-04-29 |
Research progress on Rad51C in DNA damage repair |
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| Affiliation: | 1Department of Oncology, The People's Hospital of Tianjin Seaside, Tianjin 300280, China; |
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| Abstract: | Cytotoxic substances and ionizing radiation can easily induce DNA damage, and double strand breaks (DSBs) are the main form of DNA damage. DNA damage can activate intracellular DNA damage responses and further induce related biological effects, such as DNA damage repair and cell cycle arrest. Homologous recombination (HR) is the primary DSB repair mechanism in eukaryotes. Abnormal expression of Rad51C, which is a key factor in the HR pathway, may result in DNA repair disorder, genomic instability, and eventually lead to tumor formation. In recent studies, researchers considered Rad51C as a potential target for cancer treatment. We reviewed the research progress on Rad51C in DNA damage repair and radiotherapy. |
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| Keywords: | neoplasm gene DNA damage recombination/homologous recombination Rad51C |
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