| 恶性肿瘤相关噬血细胞综合征的研究新进展* |
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| 引用本文： | 周玉兰,张荣艳,李菲.恶性肿瘤相关噬血细胞综合征的研究新进展*[J].中国肿瘤临床,2016,43(21):958-961. |
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| 作者姓名： | 周玉兰 张荣艳 李菲 |
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| 作者单位： | 作者单位:南昌大学第一附属医院血液科(南昌市330006) |
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| 基金项目： | 本文课题受国家自然科学基金项目(编号81560036)，江西省青年科学家培养项目(编号20153BCB23040)资助This study was supported by the National Natural Science Foundation of China(81560036)，the Young Scientist Training Pro-gram of Jiangxi Province(20153BCB23040) |
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| 摘 要： | 噬血细胞综合征（hemophagoc yticlymphohistiocytosis，HLH ）是由感染、风湿免疫和恶性肿瘤等多种致病因素引发的高炎症反应综合征。其中恶性肿瘤相关的噬血细胞综合征（malignancy-associated hemophagocytic lymphohistiocytosis，MAHS）起病凶险、误诊率和死亡率均较高，之前对其诊断和治疗尚未达成共识。为了更好地指导临床，2015年国际组织细胞协会（HLH ）对MAHS的认识达成专家共识。本文将结合近些年MAHS 的研究进展和2015年MAHS 专家共识做一综述。
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| 关 键 词： | 恶性肿瘤 噬血细胞综合征 诊断 治疗 |
| 收稿时间： | 2016-05-23 |
Research progress on malignancy-associated hemophagocytic lymphohistiocytosis |
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| Institution: | Department of Hematology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China |
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| Abstract: | Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory response syndrome induced by various pathogenic fac-tors, such as infection, rheumatic disease, and malignancy. Malignancy-associated hemophagocytic lymphohistiocytosis (MAHS) is a life-threatening disease with high rates of misdiagnosis and mortality. The diagnosis and treatment of MAHS have not been standard-ized until consensus recommendations were developed by the Study Group on Hemophagocytic Lymphohistiocytosis subtypes of the Histiocyte Society in 2015. This article reviews the consensus recommendations and recent advances in MAHS. |
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| Keywords: | malignancy hemophagocytic lymphohistiocytosis diagnosis treatment |
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