EGFR-TKIs 在晚期EGFR受体突变肺鳞癌患者中的临床应用 |
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引用本文: | 吴洪波,李明智,史亮,陶虹,唐俊舫,刘喆. EGFR-TKIs 在晚期EGFR受体突变肺鳞癌患者中的临床应用[J]. 中国肿瘤临床, 2016, 43(24): 1103-1105. DOI: 10.3969/j.issn.1000-8179.2016.24.063 |
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作者姓名: | 吴洪波 李明智 史亮 陶虹 唐俊舫 刘喆 |
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作者单位: | 作者单位:首都医科大学附属北京胸科医院肿瘤科(北京市101149) |
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摘 要: | 目的:探讨表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor tyrosine kinase inhibitors,EGFR-TKIs)对具有表皮生长因子受体(epidermal growth factor receptor ,EGFR)突变的晚期肺鳞癌患者临床疗效。方法:回顾性分析首都医科大学附属北京胸科医院2010年1 月至2016年7 月收治的2 317 肺鳞癌患者,筛选出有明确随访记录的7 例确诊具有EGFR 突变的肺鳞癌患者,使用EGFR-TKI 如吉非替尼、厄洛替尼治疗,直至疾病进展(progressive disease ,PD)。 结果:使用EGFR-TKI 治疗后,患者客观缓解率(objectire response rate ,ORR )42.9% ,疾病控制率(disease control rate ,DCR )100%(7/ 7),中位无进展生存期6.1 个月。结论:EGFR-TKI 对EGFR 突变的肺鳞癌患者具有一定临床疗效。但本研究病例数少仅有7 例,亟需更多的病例来进行补充研究及验证上述结论。
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关 键 词: | 表皮生长因子受体 酪氨酸激酶抑制剂 肺鳞状细胞癌 基因突变 |
收稿时间: | 2016-09-08 |
Clinical efficacy of EGFR-TKIs for advanced squamous-cell lung cancer patients with EGFR mutations |
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Affiliation: | Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. |
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Abstract: | Abstrac Objective:To investigate the clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of squamous-cell lung cancer patients with EGFR mutations. Methods:We screened out seven patients who were diag-nosed with EGFR mutations and received EGFR-TKIs, such as gifitinib or erlotinib, from 2,317 squamous-cell lung cancer patients treat-ed at the Beijing Chest Hospital from January 2010 to July 2016. Results:After using EGFR-TKIs, the objective response rate was 42.9%, the disease control rate was 100%, and the median progression-free survival was 6.1 months. Conclusion:EGFR-TKIs exert a certain clinical curative effect on patients with EGFR mutations in squamous-cell lung cancer. However, given that only seven cases are pre-sented in this research group, more cases are needed for further research to verify the above conclusion. |
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Keywords: | epidermal growth factor receptor tyrosine kinase inhibitors squamous-cell lung cancer mutation |
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