乳腺癌新辅助化疗患者病理完全缓解的影响因素及生存分析*

目的：探讨乳腺癌新辅助化疗患者病理完全缓解的影响因素及病理完全缓解对预后的影响。方法：选择河南省肿瘤医院乳腺科2008年1 月至2014年12月女性乳腺癌新辅助化疗患者267 例作为研究对象，收集患者的临床和病理资料，随访患者的生存情况。结果：单因素分析显示新辅助化疗病理完全缓解患者的体质量、哺乳时间、化疗周期、肿瘤直径和未病理完全缓解患者比较，差异均具有统计学意义（P < 0.05）；病理完全缓解患者ER、PR、HER-2 和分子分型与未病理完全缓解比较，差异均有统计学意义（P < 0.05）。 多因素分析发现体质量和ER是乳腺癌患者新辅助化疗病理完全缓解的独立预测因素（P < 0.05）。 生存分析病理完全缓解患者和未病理完全缓解患者的无病生存期和总生存期比较，差异无统计学意义（P > 0.05）。 结论：乳腺癌患者体质量和ER是新辅助化疗病理完全缓解的独立预测因素，新辅助化疗病理完全缓解对患者生存无显著影响。

Factors affecting complete pathological remission in neoadjuvant chemotherapy patients with breast cancer and survival analysis

Objective:To investigate the factors affecting complete pathological remission in neoadjuvant chemotherapy patients with breast cancer and the influence of complete pathological remission on prognosis. Methods:A total of 267 cases of neoadjuvant chemotherapy patients with breast cancer were selected for this study from January 2008 to December 2014 in our hospital. The clinical and pathological data of the patients were collected. Moreover, the survival of the patients was followed up. Results:Univariate analysis showed that differences in weight, feeding time, cycles of chemotherapy, and tumor size between complete pathological remission and incomplete pathological remission patients subjected to neoadjuvant chemotherapy were statistically significant (P<0.05). The differences in ER, PR, HER 2, and molecular typing between complete pathological remission and incomplete pathological remission patients subjected to neoadjuvant chemotherapy were statistically significant (P<0.05). Multivariate analysis showed that the weight and ER were independent predictors of complete pathological remission in patients with breast cancer undergoing neoadjuvant chemotherapy (P<0.05). Survival analysis showed that differences in the disease-free survival and overall survival between complete pathological remission and incomplete pathological remission patients undergoing neoadjuvant chemotherapy were statistically insignificant (P>0.05). Conclusion:The weight and ER of breast cancer patients in neoadjuvant chemotherapy were independent predictors of complete pathological remission. The complete pathological remission due to neoadjuvant chemotherapy had an insignificant effect on survival.