2型糖尿病患者体质成分与骨密度的关系

目的 分析2型糖尿病患者体质成分与骨密度的相互关系，以阐明躯体脂肪含量和肌肉含量在维持骨量中的作用。方法 采用双能X线分析仪（DEXA）测定76例2型糖尿病患者全身各部位的骨密度和肌肉、脂肪含量，并根据腰椎骨密度值将病人分为骨质疏松组19例与非骨质疏松组57例。结果 两组间体重指数、全身及局部脂肪含量无显著差异（P＞0．05），骨质疏松组各部位的骨密度和肌肉含量明显较非骨质疏松组低（P＜0．05－0．01）。糖尿病患者骨密度与全身及局部脂肪含量无明显相关性，而与肌肉含量呈显著正相关（P＜0．01）。结论 2型糖尿病患者肌肉组织比脂肪组织对骨密度有更显著的影响作用。

Relationship between body composition and bone mineral density in patients with type 2 diabetes meilitus

Objective To evaluate the association of body composition with bone mineral density(BMD) in patients with type 2 diabetes mellitus,and to assess the role of fat and lean masses in maintaining the bone content. Methods 76 type 2 diabetics with mean age of 63^8 years,mean duration of disease 6^9 years,mean HbA 1c 9^2% were involved in the study.BMD,lean mass,fat mass of total and regional part of the body were determined using dual energy X|ray absorptiometry (DEXA).The patients were divided into two groups according to BMD of lumbar spine, 2|4:group 1 with osteoporosis ( n= 19) and group 2 without osteoporosis( n =57). Results There were no significant differences in body mass index(BMI) and fat mass between two groups ( P >0^05).There were significant reductions in BMD and lean mass in regional part of the body in group 1 compared with group 2.There were no correlations between BMD and fat mass in total or regional part of the body ( P >0^05).There were significant positive correlations between BMD and lean mass in regional part of the body in diabetics( P >0^01). Conclusion The lean mass has a more important effect on BMD than the fat mass in patients with type 2 diabetes mellitus.