SARS患者康复期肺功能的变化

目的了解严重急性呼吸综合征(SARS)患者康复期肺功能的特征性及其变化规律。方法对26例SARS患者出院后每隔3个月进行1次肺功能检查，分析康复期肺功能各指标的意义。结果SARS患者发病后第3～6个月肺功能主要表现为限制性通气功能障碍和弥散功能障碍。不同时间段(3～6个月、6～9个月、9～12个月、12～15个月、15～17个月)的用力肺活量(FVC)、1秒用力呼气容积(FEV1.0)、功能残气量(FRC)和残气容积(RV)差异均无显著性，但随康复时间的延长而逐渐增加；同时FEV1.0／FVC变化不大；而肺总量(TLC)和肺一氧化碳弥散量(DLCO)在不同时间段均有不同程度的好转。结论SARS患者发病后肺功能的损害主要表现为限制性通气功能障碍和弥散功能障碍，但随康复时间的延长两者均逐渐恢复。

Changes in pulmonary function in severe acute respiratory syndrome patients during convalescent period

Objective To investigate the changes and pattern of pulmonary function in severe acute respiratory syndrome (SARS) patients during convalescent period. Methods Pulmonary function tests were performed in 26 SARS convalescent patients regularly every 3 months after their discharge from hospital. The significance of changes in pulmonary function indexes was analyzed. Results Restrictive pulmonary ventilation function and diffusing dysfunction of the lung were found in one third of the patients during third to sixth month from onset. There was a little improvement in forced vital capacity (FVC), one second forced expiratory volume (FEV_ 1.0 ), functional residual capacity (FRC) and residual volume (RV) as convalescent period was prolonged, but no difference was found betweendifferent stages (36 months, 69 months, 912 months , 1215 months and 1517 months). Meanwhile, the FEV_ 1.0 /FVC showed no significant change. However, there was an obvious improvement in total lung capacity (TLC) and diffusing capacity of the lung for carbon monoxide (DLCO) with the elapse of time, and also a significant difference was found betweenthe later stage and the earlier stage. Conclusion Pulmonary dysfunction is found among some SARS patients after convalescence presenting mainly as restrictive ventilatory function and diffusing capacity abnormality. These dysfunctions would improve gradually with the elapse of time.