| 青龙衣不同提取部位的抗肿瘤作用研究 |
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| 引用本文： | 季宇彬,马宏图,杨波,汲晨锋. 青龙衣不同提取部位的抗肿瘤作用研究[J]. 中草药, 2004, 35(10): 1145-1147 |
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| 作者姓名： | 季宇彬 马宏图 杨波 汲晨锋 |
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| 作者单位： | 哈尔滨商业大学药物研究所,博士后科研工作站,黑龙江,哈尔滨,150076 |
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| 基金项目： | 黑龙江省自然科学基金项目(ZLY03-04) |
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| 摘 要： | 目的 观察青龙衣不同提取部位的抗肿瘤作用。方法 制备S180和H22荷瘤小鼠模型，青龙衣不同提取部位ip给药，观察其对S180小鼠的抑瘤作用及对胸腺、脾脏器官指数的影响，对S180和H22荷瘤小鼠癌细胞膜和红细胞膜表面唾液酸(SA)含量的影响。结果 青龙衣冷、热醇提取部位对S180荷瘤小鼠均有明显的抑瘤作用，并呈良好的剂量效应关系；对H22荷瘤小鼠可延长生存期；冷、热醇提取部位能显著降低S180和H22小鼠肿瘤细胞膜表面SA含量，同时显著提高荷瘤小鼠红细胞膜表面SA含量。结论 青龙衣冷、热醇提取部位具有抗肿瘤作用。
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| 关 键 词： | 青龙衣不同提取部位 唾液酸 抗肿瘤作用 |
| 文章编号： | 0253-2670(2004)10-1145-03 |
| 收稿时间： | 2004-01-05 |
Antitumor effects of different extract fractions from Qinglongyi |
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| JI Yu-bin,MA Hong-tu,YANG Bo and JI Chen-feng. Antitumor effects of different extract fractions from Qinglongyi[J]. Chinese Traditional and Herbal Drugs, 2004, 35(10): 1145-1147 |
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| Authors: | JI Yu-bin MA Hong-tu YANG Bo JI Chen-feng |
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| Affiliation: | Postdoctoral Programme, Institute of Materia Medica, Harbin Commercial University, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin Commercial University, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin Commercial University, Harbin 150076, China;Postdoctoral Programme, Institute of Materia Medica, Harbin Commercial University, Harbin 150076, China |
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| Abstract: | Object To observe antitumor effects of different extract fractions from Qinglongyi (DEQ). Methods S180-mice and H22-mice were given by ip as model. Antitumor effects of DEQ on S180-mice were observed, and also the effect on indexes of thymus and spleen, sialic acid (SA) content in cancer cell membrane and erythrocyte membrane in S180-mice and H22-mice. Results The two extract fractions by cold and hot alcohol have obvious antitumor effects in a dose-effect manner to S180-mice, and can prolong H22-mice life. The two extract fractions from Qinlongyi can significantly decrease SA in cancer cell membrane and increase SA in erythrocyte membrane. Conclusion The two extract fractions from Qinglongyi have antitumor effects. |
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| Keywords: | different extract fractions from Qinglongyi (DEQ) sialic acid antitumor effect |
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