参芪补肺汤对慢性阻塞性肺疾病稳定期肺气虚证患者肺功能的影响

目的:评价参芪补肺汤对慢性阻塞性肺疾病(COPD)稳定期肺气虚证患者的临床疗效、肺功能及安全性的影响.方法:采用随机对照、单盲临床试验设计,共纳入60例COPD稳定期肺气虚证受试患者,随机分为治疗组(n=30)和对照组(n=30),疗程3月.结果:治疗组总有效率89.66％,总显效率55.17％；对照组总有效率66.67％,总显效率23.33％,2组间疗效比效有统计学意义(P＜0.05).肺功能比较,治疗组各项参数与治前比较有上升趋势,但差异均无统计学意义,对照组各项参数与治前比较有下降趋势,但差异均无统计学意义；两组间各指标比较差异均有统计学意义(P≤0.05),提示治疗组稳定患者肺功能优于对照组.观察中未发现明显不良反应.结论:参芪补肺汤治疗慢性阻塞性肺疾病稳定期肺气虚证患者疗效确切,能稳定肺功能且安全.

Effects of Lung Function of Shenqi Bufei Tang on Stable COPD Patient with Lung-Qi Deficiency Syndrome

Objective:To estimate the clinical effects,lung function and safety of Shenqi Bufei Tang on stable chronic obstructive pulmonary disease(COPD) patient with Lung-Qi deficiency syndrome.Method:A randomized,stratified,single-blind,controlled trial was designed.60 stable COPD patients with Lung-Qi deficiency syndrome in mild or moderate degree were allocated by random number table to therapy group(T,n=30) and control group(C,n=30).The patients received single conventional therapy in the group C and conventional therapy and Shenqi Bufei Tang in the group T for 3 months.Efficacy measures were clinical symptom and lung function and adverse effect in the course of the treatment and after the treatment.Result:The markedly effective rates were 55.17% and the effective rates were 89.66% in treatment group VS.the markedly effective rates of 23.33%,the effective rates of 66.67% in the control group.The clinical symptoms improvement of the therapy group were better than that of the control group(P<0.05).There was a uptrend to FVC,FEV1,FEV1% pred,FEV1/FVC of the group T after treatment,but there were not significant difference as compared with before treatment.There was a downtrend to FVC,FEV1,FEV1% pred,FEV1/FVC of the group C after treatment,but there were no significant differences as compared with before treatment.There were significant differences in FVC,FEV1,FEV1%pred,FEV1/FVC between the group T and the group C(P≤0.05).Conclusion :The management of the conventional therapy associated with Shenqi Bufei Tang could improve the symptoms and stabilize lung function significantly compared with the single conventional therapys on stable COPD patient with lung-Qi deficiency syndrome.Shenqi Bufei Tang may be beneficial and safe in treatment of stable COPD.