| 黄连非生物碱类化学成分研究 |
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| 引用本文： | 陈亮,王磊,张庆文,张声源,叶文才. 黄连非生物碱类化学成分研究[J]. 中国中药杂志, 2012, 37(9): 1241-1244 |
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| 作者姓名： | 陈亮 王磊 张庆文 张声源 叶文才 |
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| 作者单位： | 1. 暨南大学药学院中药及天然药物研究所&中药药效物质基础及创新药物研究广东省高校重点实验室,广东广州,510632
2. 澳门大学中华医药研究院,澳门,999078 |
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| 基金项目： | 中国博士后特别资助项目(201104369) |
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| 摘 要： | 目的:对黄连中非生物碱类化学成分进行分离和鉴定。方法:利用各种色谱方法进行分离纯化,根据理化性质和NMR,MS等波谱技术鉴定化合物的结构。结果:从黄连乙醇提取物中分离鉴定了13个化合物,包括7个木脂素,3个简单苯丙素,2个黄酮,1个酚酸,分别为erythro-guaiacylglycerol-8-O-4’-(coniferyl alcohol)ether(1),threo-guaiacylglycerol-8-O-4’-(coniferyl al-cohol)ether(2),(+)-松脂醇[(+)-pinoresinol,3],(+)-5’-甲氧基松脂素[(+)-medioresinol,4],(+)-落叶松树脂醇[(+)-lar-iciresinol,5],(+)-5’-甲氧基落叶松树脂醇[(+)-5’-methoxylariciresinol,6],(+)-异落叶松树脂醇[(+)-isolariciresinol,7],绿原酸(chlorogenic acid,8),阿魏酸(ferulic acid,9),Z-咖啡酸硬脂醇酯(Z-octadecyl caffeate,10),鼠李素(rhamnetin,11),汉黄芩素(wogonin,12),香草酸(vanillic acid,13)。结论:化合物1,2,4,6,10～13为首次从黄连属植物中分离得到。
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| 关 键 词： | 黄连 化学成分 木脂素 黄酮 |
| 收稿时间： | 2011-12-08 |
Non-alkaloid chemical constituents from Coptis chinensis |
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| CHEN Liang,WANG Lei,ZHANG Qingwen,ZHANG Shengyuan and YE Wencai. Non-alkaloid chemical constituents from Coptis chinensis[J]. China Journal of Chinese Materia Medica, 2012, 37(9): 1241-1244 |
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| Authors: | CHEN Liang WANG Lei ZHANG Qingwen ZHANG Shengyuan YE Wencai |
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| Affiliation: | Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China;Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China;Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China;Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China;Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Abstract: | Objective: To separate and identify chemical constituents from Coptis chinensis. Method: The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of their physicochemical properties using spectral techniques such as NMR and MS. Result: Thirteen compounds were separated from ethanol extracts of C. chinensis,including seven lignans,three simple phenylpropanoids,two flavones and one phenolic acid,and identified as erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol)ether(1),threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol)ether(2),(+)-pinoresinol(3),(+)-medioresinol(4), (+)-lariciresinol(5),(+)-5'-methoxylariciresinol(6),(+)-isolariciresinol(7), chlorogenic acid(8),ferulic acid(9),Z-octadecyl caffeate(10),rhamnetin(11),wogonin(12),and vanillic acid(13). Conclusion: Compounds 1,2,4,6,10-13 were separated from the genus Coptis for the first time. |
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| Keywords: | Coptis chinensis chemical constituent lignan flavone |
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