| 综合评分法优化葛根芩连汤提取工艺 |
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| 引用本文： | 章军,刘宇政,王跃生,饶毅,魏慧珍,刘安. 综合评分法优化葛根芩连汤提取工艺[J]. 中国实验方剂学杂志, 2012, 18(2): 1-3 |
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| 作者姓名： | 章军 刘宇政 王跃生 饶毅 魏慧珍 刘安 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700
2. 江西中医学院,南昌,330006 |
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| 基金项目： | 国家"973计划"项目(2010CB530602);重大新药创制科技重大专项(2009ZX09313-038) |
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| 摘 要： | 目的:优选葛根芩连汤的最佳提取工艺。方法:采用正交设计法,以复方中12个有效成分含量为综合评分标准进行数据分析,对加水量、提取时间和提取次数进行优化。结果:煎煮次数具有极显著性影响,加水量和煎煮时间没有显著性影响。最佳煎煮工艺为8倍量水提取3次,每次1 h。结论:优化后的工艺稳定可靠,可为葛根芩连汤临床用药煎煮及相关制剂的工业生产提供参考。
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| 关 键 词： | 葛根芩连汤 正交设计 综合评分法 |
| 收稿时间： | 2011-08-09 |
Optimization of Extraction Technology for Gegen Qinlian Decoction with Multi-index Comprehensive Evaluation Method |
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| ZHANG Jun,LIU Yu-zheng,WANG Yue-sheng,RAO Yi,WEI Hui-zhen and LIU An. Optimization of Extraction Technology for Gegen Qinlian Decoction with Multi-index Comprehensive Evaluation Method[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(2): 1-3 |
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| Authors: | ZHANG Jun LIU Yu-zheng WANG Yue-sheng RAO Yi WEI Hui-zhen LIU An |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Institute of Chinese Materia Medica, China Academy of chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Institute of Chinese Materia Medica, China Academy of chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Objective: To establish the optimal extraction technology of Gegen Qinlian decoction. Method: A HPLC method was established to simultaneously determine 12 active ingredients in the extractions of Gegen Qinlian decoction. Based on the orthogonal design of L9(34) and the weighted method, three factors including the multiple water, decocting time, and extracting times were evaluated. Result: Significant effect was observed in extracting times. The optimal extraction technology was 8 times volume of water extracting 3 times with 1 h for each time. Conclusion: The extraction technology optimized with multi-index comprehensive evaluation method is reasonably practicable. It could be used in future large-scaled preparation of Gegen Qinlian decoction. |
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| Keywords: | Gegen Qinlian decoction orthogonal design multi-index comprehensive evaluation method |
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