|
|||||
|
|
| 知母宁抗乙肝病毒作用的体内外实验研究 | |
| 引用本文： | 高洁,李明,刘妮.知母宁抗乙肝病毒作用的体内外实验研究[J].山西中医学院学报,2007,8(2):16-18. |
| 作者姓名： | 高洁 李明 刘妮 |
| 作者单位： | 1. 广州中医药大学方剂学教研室,广东,广州,510006 2. 三九药业生化研究所,广东,深圳,518026 3. 广州中医药大学病毒研究所,广东,广州,510405 |
| 基金项目： | 三九药业企业博士后资助项目 |
| 摘 要： | 目的:观察知母宁的抗乙肝病毒作用。方法:观察不同浓度知母宁对体外培养的2.2.15细胞分泌HBsAg、HBeAg的抑制作用及对乙肝模型鸭DHBV-DNA的影响。结果:知母宁浓度为4mg/mL时对2.2.15细胞分泌HBeAg有明显的抑制作用;以200mg/kg治疗乙肝模型鸭10d后DHBV-DNA水平明显降低。结论:知母宁有抗乙肝病毒的作用,其机制可能与抑制HBV-DNA的复制有关。 |
| 关 键 词： | 知母宁 乙肝病毒 2.2.15细胞 |
| 文章编号： | 24367431 |
| 修稿时间： | 01 9 2007 12:00AM |
Antiviral Effect of Chinonin on HBV in Vivo and in Vitro |
|
| Gao Jie,Li Ming,Liu Ni.Antiviral Effect of Chinonin on HBV in Vivo and in Vitro[J].Journal of Shanxi College of Traditional Chinese Medicine,2007,8(2):16-18. | |
| Authors: | Gao Jie Li Ming Liu Ni |
| Institution: | Guangzhou University of TCM, Guangzhou Guangdong 510006 |
| Abstract: | Objective:To study the effect of Chinonin on HBV in vivo and in vitro. Methods:The level of HBsAg and HBeAg secreted from HepG2.2.15 cells and the copies of DNA of duck hepatitis B virus(DHBV)models which were treated with Chinonin were detected. Results:Chinonin can restrain the secretion of HBeAg of HepG2.2.15 cells with the dose of 4mg/mL in vitro. In vivo,chinonin can decreased significantly DHBV level of duck model after 10 days treatment with the dose of 200 mg/kg. Conclusion:Chinonin has the effect of decreasing the secretion of HBeAg,which maybe relate to restraining the duplication of HBV-DNA. |
| Keywords: | DHBV-DNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |